|
| Status |
Public on Mar 30, 2019 |
| Title |
MicroRNA-223 ameliorates nonalcoholic steatohepatitis and cancer by targeting multiple inflammatory and oncogenic genes in hepatocytes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Here, we found that microRNA-223 (miR-223) was highly elevated in hepatocytes after high fat diet (HFD) feeding in mice and in human nonalcoholic steatohepatitis (NASH) samples. Genetic deletion of the miR-223 induced a full spectrum of nonalcoholic fatty liver disease (NAFLD) in mice after long-term (up to one year) HFD feeding including NASH-related steatosis, inflammation, fibrosis and HCC. To better explore the mechanisms underlying the abnormalities observed in HFD-fed miR-223KO mice, we examined hepatic gene expression in 3-month-HFD-fed WT and miR-223KO mice by microarray analysis. Finally, we revealed that miR-223 plays a key role in controlling steatosis-to-NASH progression by inhibiting hepatic Cxcl10 and Taz expression.
|
| |
|
| Overall design |
Two-condition experiment, WT and miR-223KO.
|
| |
|
| Contributor(s) |
He Y, Cai Y, Gao B |
| Citation(s) |
30964207 |
| |
| Submission date |
Mar 29, 2019 |
| Last update date |
Jul 03, 2019 |
| Contact name |
Yong He |
| E-mail(s) |
yong.he.nih@gmail.com
|
| Phone |
3014807478
|
| Organization name |
NIAAA/NIH
|
| Street address |
5625 Fishers lane Room 2S-12
|
| City |
Rockville |
| State/province |
MD |
| ZIP/Postal code |
20852 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA529919 |
Less...
More...