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| Status |
Public on Feb 24, 2020 |
| Title |
Transcriptional network controlled by Candida albicans treated by a gemini quaternary ammonium compound, 1, 5-bis(dodecyl)-1, 1, 3, 5, 5-pentamethyl-3-aza-1, 5-pentanediammonium ditetrafluoroborate (PMT12-BF4) |
| Organism |
Candida albicans |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In order to identify genes regulated by PMT12-BF4, we compared the genome-wide expression profile in wild-type strain SC5314 untreated or treated with PMT12-BF4 via RNA sequencing. Results showed that in C. albicans 69 genes were up-regulated and 30 genes were down-regulated in the presence of PMT12-BF4. Up-regulated genes were mostly involved in iron ion-related functions (e.g. RBT5, CFL5, CFL4, FET34, FET31 etc.), and down-regulated genes were largely involved in oxidoreductase activity, vitamin binding and coenzyme binding.
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| Overall design |
Total mRNAs extracted from C. albicans wild-type SC5314 treated or untreated with PMT12-BF4 were analyzed using RNA sequencing.
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| Contributor(s) |
Hsu L, Chen Y |
| Citation(s) |
32076050 |
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| Submission date |
Apr 02, 2019 |
| Last update date |
Feb 24, 2020 |
| Contact name |
Li-Hang Hsu |
| E-mail(s) |
a50104123@gmail.com
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| Organization name |
National Taiwan University
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| Department |
Plant Pathology and Microbiology
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| Lab |
Applied Microbiology Lab.
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| Street address |
No. 1, Sec. 4, Roosevelt Rd
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| City |
Taipei city |
| State/province |
Taiwan (R.O.C) |
| ZIP/Postal code |
10671 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL19036 |
Illumina HiSeq 2500 (Candida albicans) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA530417 |
| SRA |
SRP190143 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE129191_PMT12-BF4.treated-vs-untreated.txt.gz |
868.8 Kb |
(ftp)(http) |
TXT |
| GSE129191_RAW.tar |
210.0 Kb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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