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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 03, 2021 |
| Title |
Expression data from microglia in Abeta and TAU mouse models of Alzheimer Disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Microglia activation is a hallmark in Alzheimer Disease. Non-active and Active microglia were isolated from young and aged WT mice and before- and after- pathology mouse models of Alzheimer Disease.
Microarray analysis was used to determine the global gene expression programe in microglia during pathological (Abeta or TAU pathology) versus control state.
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| Overall design |
Cortical plus hippocampal microglia (CD45+ and CD11b+) were isolated from WT, APP and TAU mice at 3 and 9-12 month-old. Active microglia were isolated as Clec7a+ microglia.
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| Contributor(s) |
Romero-Molina C, Virtudes Sanchez-Mico M, Vizuete M, Vitorica J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Apr 03, 2019 |
| Last update date |
Mar 05, 2021 |
| Contact name |
Carmen Romero-Molina |
| E-mail(s) |
cromero15@us.es
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| Phone |
955923052
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| Organization name |
University of Seville. Institute of Biomedicine of Seville
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| Department |
Faculty of Pharmacy. Biochemistry and Molecular Biology
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| Lab |
111
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| Street address |
Profesor Garcia Gonzalez, 2
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| City |
Seville |
| State/province |
Seville |
| ZIP/Postal code |
41012 |
| Country |
Spain |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (23)
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| GSM3704174 |
Microglia WT 3m, biological rep4 |
| GSM3704175 |
Microglia APP 3m, biological rep1 |
| GSM3704176 |
Microglia APP 3m, biological rep2 |
| GSM3704177 |
Microglia APP 3m, biological rep3 |
| GSM3704178 |
Microglia TAU 3m, biological rep1 |
| GSM3704179 |
Microglia TAU 3m, biological rep2 |
| GSM3704180 |
Microglia TAU 3m, biological rep3 |
| GSM3704181 |
Microglia TAU 3m, biological rep4 |
| GSM3704182 |
Microglia WT 12m, biological rep1 |
| GSM3704183 |
Microglia WT 12m, biological rep2 |
| GSM3704184 |
Microglia WT 12m, biological rep3 |
| GSM3704185 |
Microglia WT 12m, biological rep4 |
| GSM3704186 |
Microglia APP 12m, biological rep1 |
| GSM3704187 |
Microglia APP 12m, biological rep2 |
| GSM3704188 |
Microglia APP 12m, biological rep3 |
| GSM3704189 |
Microglia APP 12m, biological rep4 |
| GSM3704190 |
Microglia TAU12m, biological rep1 |
| GSM3704191 |
Microglia TAU12m, biological rep2 |
| GSM3704192 |
Microglia TAU12m, biological rep3 |
| GSM3704193 |
Microglia TAU12m, biological rep4 |
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| Relations |
| BioProject |
PRJNA530765 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE129296_RAW.tar |
25.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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