|
| Status |
Public on May 11, 2019 |
| Title |
Group 3 innate lymphoid cells mediate early protective immunity against Mycobacterium tuberculosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report the phenotype of human lung ILC2 and ILC3 populations from individuals with tuberculosis (TB) and non-TB cancer controls. We find that ILC2s demonstrate moderate transcriptional differences in TB infection, whereas ILC3s demonstrate large differences.
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| |
|
| Overall design |
ILC2s and ILC3s were purified by FACS from lung biopsies from TB infected lung tissue and peripheral healthy lung tissue from individuals with cancer. Low-input RNA-seq was performed on 1-3 replicates (dependent on cell number) on 5 individuals with TB infection and 2 controls.
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| |
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| Contributor(s) |
Leslie A, Khader S |
| Citation(s) |
31168092 |
| |
| Submission date |
May 10, 2019 |
| Last update date |
Jun 25, 2019 |
| Contact name |
Alasdair Leslie |
| E-mail(s) |
al.leslie@ahri.org
|
| Organization name |
African Health Research Institute
|
| Lab |
Leslie Lab
|
| Street address |
719 Umbilo Road
|
| City |
Durban |
| ZIP/Postal code |
4001 |
| Country |
South Africa |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (24)
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| Relations |
| BioProject |
PRJNA542348 |
| SRA |
SRP197580 |
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