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| Status |
Public on Dec 10, 2019 |
| Title |
Shp-deletion induces dissociation of steatosis and inflammation in NASH |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Two months-old Shp flox/flox male mice were injected with either AAV8 expressing Cre recombinase driven by the thyroxine-binding globulin (Tbg) promoter (AAV8-Tbg-Cre) or control AAV8 (AAV8-Tbg-null) and fed chow or a diet enriched in high fat, cholesterol, and fructose (Research diet D09100301: 40 kcal% fat, 2% cholesterol, 20 kcal% fructose, hereafter referred to as HFCF diet) for 3 months. Liver RNA was isolated and submitted to RNA-seq.
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| Overall design |
Analysis of hepatic gene expression from 3 WT mice on chow, 3 Shp Hep-/- mice on chow, 3 WT mice on HFCF diet, and 3 Shp Hep-/- mice on HFCF diet
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| Contributor(s) |
Magee NS, Zhang Y |
| Citation(s) |
31831621 |
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| Submission date |
Jul 01, 2019 |
| Last update date |
Mar 10, 2020 |
| Contact name |
Yuxia Zhang |
| E-mail(s) |
lzhang5@kumc.edu
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| Phone |
9135881749
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| Organization name |
University of Kansas Medical Center
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| Department |
Pharmacology, Toxicology, and Therapeutics
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| Street address |
3901 Rainbow Blvd, Hemenway 4001
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| City |
kansas city |
| State/province |
KS |
| ZIP/Postal code |
66160 |
| Country |
USA |
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| Platforms (1) |
| GPL15103 |
Illumina HiSeq 1000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA551941 |
| SRA |
SRP212664 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE133566_HSKO_processed_data.txt.gz |
1.8 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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