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| Status |
Public on Aug 20, 2019 |
| Title |
LSD1 inhibition promotes epithelial differentiation through derepression of fate- determining transcription factors [inhibitors] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report the impact of the pharmacological inhibition of the Histone 3 Lysine 4 demethylase (H3K4) LSD1 (KDM1A) enzymatic activity on genome-wide gene expression in normal human epidermal keratinocyte (NHEK)
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| Overall design |
Examination of genome-wide gene expression changes triggered by the pharmacological inhibition of LSD1 (KDM1A) Histone 3 Lysine 4 (H3K4) histone demethylase activity in normal human epidermal keratinocyte using 2 different LSD1 inhibitors: GSK-LSD1 (Cayman Chemical, Cat# 16439) or 2-PCPA (BPS Bioscience, Cat# 27305) and different treatment length (2d or 6d).
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| |
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| Contributor(s) |
Egolf S, Aubert Y, Doepner M, Anderson A, Maldonado-Lopez A, Pacella G, Lee J, Ko EK, Zou J, Lan Y, Simpson C, Ridky T, Capell BC |
| Citation(s) |
31433976 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| K08 AR070289 |
Epigenomic mechanisms of skin carcinogenesis |
UNIVERSITY OF PENNSYLVANIA |
Brian Capell |
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| |
| Submission date |
Jul 02, 2019 |
| Last update date |
Aug 22, 2019 |
| Contact name |
Yann Aubert |
| E-mail(s) |
yaubert@pennmedicine.upenn.edu
|
| Organization name |
University of Pennsylvania
|
| Department |
Penn Dermatology Research
|
| Lab |
Capell Lab
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| Street address |
Biomedical Research Building 421 Curie Blvd
|
| City |
Philadelphia |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (22)
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| This SubSeries is part of SuperSeries: |
| GSE133766 |
LSD1 inhibition promotes epithelial differentiation through derepression of fate- determining transcription factors |
|
| Relations |
| BioProject |
PRJNA552362 |
| SRA |
SRP212802 |
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