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Status |
Public on Oct 31, 2008 |
Title |
Mechanism and transcriptional program of YB-1 in breast cancer cell lines. |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
YB-1 controls epithelial-mesenchymal transitions by restricting translation of growth-related mRNAs and enabling expression of EMT-inducing transcription factors. We used microarrays to characterize the direct transcriptional and indirect translational regulation of mRNAs by exogenous YB-1 in breast cancer cell lines.
Keywords: gene expression profiling
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Overall design |
To evaluate this in a genome-wide manner we compared microarray expression profiles of total mRNA and mRNAs isolated from Ps (translationally active) or post-Ps (translationally inactive) fractions of MCF10AT-MSCV vs. MCF10AT-YB-1 cells
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Contributor(s) |
Sorensen P, Evdokimova V, Davicioni E |
Citation(s) |
19411069 |
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Submission date |
Oct 30, 2008 |
Last update date |
Jul 10, 2014 |
Contact name |
Elai Davicioni |
E-mail(s) |
elai.davicioni@veracyte.com
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Organization name |
Veracyte, Inc
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Street address |
9725 Lusk Blvd
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City |
San Diego |
State/province |
California |
ZIP/Postal code |
92121 |
Country |
USA |
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Platforms (1) |
GPL5188 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
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Samples (10)
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Relations |
BioProject |
PRJNA109771 |