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| Status |
Public on Oct 31, 2008 |
| Title |
Mechanism and transcriptional program of YB-1 in breast cancer cell lines. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
YB-1 controls epithelial-mesenchymal transitions by restricting translation of growth-related mRNAs and enabling expression of EMT-inducing transcription factors. We used microarrays to characterize the direct transcriptional and indirect translational regulation of mRNAs by exogenous YB-1 in breast cancer cell lines.
Keywords: gene expression profiling
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| |
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| Overall design |
To evaluate this in a genome-wide manner we compared microarray expression profiles of total mRNA and mRNAs isolated from Ps (translationally active) or post-Ps (translationally inactive) fractions of MCF10AT-MSCV vs. MCF10AT-YB-1 cells
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| |
|
| Contributor(s) |
Sorensen P, Evdokimova V, Davicioni E |
| Citation(s) |
19411069 |
| |
| Submission date |
Oct 30, 2008 |
| Last update date |
Jul 10, 2014 |
| Contact name |
Elai Davicioni |
| E-mail(s) |
elai.davicioni@veracyte.com
|
| Organization name |
Veracyte, Inc
|
| Street address |
9725 Lusk Blvd
|
| City |
San Diego |
| State/province |
California |
| ZIP/Postal code |
92121 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL5188 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version] |
|
| Samples (10)
|
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| Relations |
| BioProject |
PRJNA109771 |
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