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Series GSE134368 Query DataSets for GSE134368
Status Public on Feb 28, 2020
Title RNA-seq analysis of WT and HDAC1f/f HDAC2f/+ x CD4cre deficient activated helper T cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary CD4+ T cells have the potential to differentiate into effector cells with cytotoxic activity (CD4+ CTLs), however molecular mechanisms regulating CD4+ CTL induction are poorly understood. By analyzing mice with graded deletion of Hdac1 and Hdac2 alleles in T cells, we observed an HDAC1-HDAC2 dose-dependent induction of CD4+ CTLs. A transcriptome analysis of activated CD4+ T cells carrying a combined deletion of two Hdac1 and one Hdac2 alleles (HDAC1f/f-HDAC2f/+) revealed enrichment of gene signatures similar to CD8+ T cells and CD4+ CTLs.
Overall design mRNA expression profiles of activated CD4+ T cells isolated from WT and HDAC1f/f HDAC2f/+ (CD4-cre) mice were generated by deep sequencing.
mRNA expression profiles of activated CD4+ T cells isolated from WT and HDAC1f/f (CD4-cre) mice were generated by deep sequencing.
Contributor(s) Preglej T, Goeschl L, Ellmeier W
Citation(s) 32102981
Submission date Jul 16, 2019
Last update date Mar 01, 2020
Contact name Wilfried Ellmeier
Organization name Medical University of Vienna
Department Institute of Immunology
Street address Lazarettgase 19
City Vienna
ZIP/Postal code 1030
Country Austria
Platforms (2)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (14)
GSM3943898 WT 1
GSM3943899 WT 2
GSM3943900 WT 3
BioProject PRJNA554874
SRA SRP214857

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE134368_LG_HDAC1cKO_TH0_Daten.xlsx 4.0 Mb (ftp)(http) XLSX
GSE134368_RAW.tar 20.2 Mb (http)(custom) TAR (of TSV)
GSE134368_TP_Hdac1Hdac2_2fold.xlsx 450.7 Kb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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