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Series GSE134477 Query DataSets for GSE134477
Status Public on Jul 01, 2021
Title Transcriptomic profiling of circulating T follicular helper cells in kidney transplant recipients
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We compared the transcriptomic profile between patients without donor-specific HLA antibodies (DSA-), patients with donor-specific HLA antibodies without antibody-mediated rejection (DSA+ ABMR-) and patients with donor-specific HLA antibodies and antibody-mediated rejection (DSA+ ABMR+). We found that patient with DSA+ ABMR+ had a distinct transcriptomic profile compared to DSA- and DSA+ ABMR-, characterized by upregulation of genes encoding for germinal center T follicular helper cells function, T-B cell interaction and costimulatory molecules.
 
Overall design We analysed N=3 samples per group of patients (DSA-, DSA+ABMR-, DSA+ ABMR+), without replicates
 
Contributor(s) Louis K, Metes D, Chandran U, Chang A
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jul 18, 2019
Last update date Jul 02, 2021
Contact name Uma Chandran
E-mail(s) chandran@pitt.edu
Phone 412-648-9326
Organization name University of Pittsburgh
Department BioMedical Informatics
Street address 5150 Center Ave
City Pittsburgh
State/province PA
ZIP/Postal code 15232
Country USA
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (9)
GSM3950597 RNA-seq circulating T follicular helper cells DSA- [1TFH_S6]
GSM3950598 RNA-seq circulating T follicular helper cells DSA- [3TFH_S4]
GSM3950599 RNA-seq circulating T follicular helper cells DSA- [4TFH_S17]
Relations
BioProject PRJNA555251
SRA SRP215220

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE134477_RAW.tar 1.7 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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