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Series GSE134723 Query DataSets for GSE134723
Status Public on Jun 30, 2022
Title miRNA expression profiling in cervical cancer cells following curcumin treatment
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Cervical cancer is the second most common cancer in women worldwide. In addition to the important role played by HPV, the underlying mechanism promoting cervical tumorigenesis is complex and involves deregulation of key signaling pathways. Recently, role of miRNA mediated abnormal regulatory mechanisms is implicated in the pathogenesis of cervical cancer. Micro RNAs are regulatory, non‐coding RNAs about 21–23 nucleotides in length and effects the expression of a number of genes at the post‐transcriptional level. For the past few decades, role of curcumin in inhibiting the growth of cervical cancer and increasing the chemo and radio- sensistivity has been studied extensively. Interestingly, curcumin was shown to downregulate NF-κB, Wnt/β-catenin, TGF‐β and various other signaling pathways in cervical cancer cells. Although, a number of microarray studies have examined the use of miRNAs as cancer diagnostic markers, the regulation of miRNAs upon treatment with curcumin in cervical cancer cells has not been studied. The current study is aimed to perform miRNA profiling in cervical cancer cells following curcumin treatment and to study the role of miRNAs in regulating the different signaling pathways.
 
Overall design miRNA profiling was performed at 24 h following curcumin treatment (n=3) to SiHa cervical cancer cells. DMSO (0.4%) was used as a vehicle control (n=3) for all the experiments. Agilent one-color experiment,Organism: Homo sapiens ,Agilent Human miRNA 8x60k Arrays AMADID: 070156
 
Contributor(s) Samji P, Ganesh A, Warrier VP, Karunagaran MK
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jul 23, 2019
Last update date Jul 02, 2022
Contact name Genotypic technology
E-mail(s) sudha.rao@genotypic.co.in
Organization name Genotypic Technology
Street address 259, Apoorva 4th cross,80 feet Road,RMV 2ND STAGE
City Bangalore
State/province Karnataka
ZIP/Postal code 560094
Country India
 
Platforms (1)
GPL25134 Agilent-070156 Human_miRNA_V21.0_Microarray 046064 (miRNA ID version)
Samples (6)
GSM3964171 SiHa cells 24h post DMSO, rep1
GSM3964172 SiHa cells 24h post DMSO, rep2
GSM3964173 SiHa cells 24h post DMSO, rep3
Relations
BioProject PRJNA556228

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE134723_RAW.tar 41.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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