|
| Status |
Public on Jul 27, 2019 |
| Title |
Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
This dataset includes ATAC-Seq and RNA-seq data from rat prefrontal cortex and/or nucleus accumbens (postnatal date, PND 61), as part of characterizing how the rat brain responds to its first encounter with cocaine (PND 60) with or without preexposure to the synthetic cannabinoid WIN 55,212-2 (WIN) during adolescence (PND 42-52). WIN was administered twice daily during the latter eleven consecutive days (2 mg/kg, 3 days; 4 mg/kg, 4 days; 8 mg/kg, 4 days) and, following a week of WIN abstinence, animals were IP challenged with cocaine (10 mg/kg). Brain dissections were performed 24 hours after the cocaine IP challenge.
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| |
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| Overall design |
ATACseq in PFC in 4 treatments. RNAseq in PFC and Nacc
|
| Web link |
https://www.ncbi.nlm.nih.gov/pubmed/32312805
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| |
|
| Contributor(s) |
Melas P, Kandel D |
| Citation(s) |
32312805 |
| Submission date |
Jul 26, 2019 |
| Last update date |
Apr 23, 2020 |
| Contact name |
Philippe Melas |
| Organization name |
Columbia University
|
| Lab |
Kandel's lab
|
| Street address |
1051 Riverside Drive
|
| City |
New York |
| ZIP/Postal code |
10032 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL14844 |
Illumina HiSeq 2000 (Rattus norvegicus) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
|
| Samples (22)
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| Relations |
| BioProject |
PRJNA556851 |
| SRA |
SRP216501 |
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