|
| Status |
Public on Mar 02, 2020 |
| Title |
DNA Methylation Potential Energy Landscape Analysis of MLL-rearranged Acute Myeloid Leukemia (AML) and Normal hematopoietic precursors [WGBS] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
Acute myeloid leukemia (AML) carrying MLL rearrangements. We applied WGBS and the informME analysis pipeline to investigate the role of DNA methylation stochasticity in MLL-rearranged AML.
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| |
|
| Overall design |
WGBS was carried out on primary acute myeloid leukemia samples harboring KMT2A (MLL) rearrangements and on normal human myeloid progenitor cells.
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| |
|
| Contributor(s) |
Koldobskiy MA, Feinberg AP |
| Citation(s) |
32114880 |
| |
| Submission date |
Aug 15, 2019 |
| Last update date |
Jan 07, 2022 |
| Contact name |
Michael A Koldobskiy |
| Organization name |
Johns Hopkins University
|
| Department |
Center for Epigenetics
|
| Lab |
Rangos 573
|
| Street address |
855 N. Wolfe St.
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (15)
|
|
| Relations |
| BioProject |
PRJNA560375 |
| SRA |
SRP353670 |
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