|
| Status |
Public on Oct 20, 2019 |
| Title |
Transcriptomic profiles of Pseudomonas aeruginosa PAO1 grown in the presence or absence of mucins or mucin-glycans |
| Organism |
Pseudomonas aeruginosa |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We use high-throughput sequencing to profile the response of the opportunistic mucosal pathogen Pseudomonas aeruginosa to mucins and mucin-glycans from the mucosal niche. We find that P. aeruginosa undergoes a genome-wide phenotypic shift in response to mucins and their attached glycans. Specifically, nearly all virulence pathways are downregulated in response to these host-produced factors. This study provides a framework for understanding how the host environment regulates bacterial function.
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| |
|
| Overall design |
Examination of differential gene expression in Pseudomonas aeruginosa in response to mucin and mucin sugars
|
| |
|
| Contributor(s) |
Ribbeck K, Wheeler K |
| Citation(s) |
31611643 |
| |
| Submission date |
Aug 21, 2019 |
| Last update date |
Jan 22, 2020 |
| Contact name |
Katharina Ribbeck |
| E-mail(s) |
ribbeck@mit.edu
|
| Organization name |
Massachusetts Institute of Technology
|
| Department |
Biological Engineering
|
| Lab |
Ribbeck
|
| Street address |
21 Ames St
|
| City |
Cambridge |
| State/province |
Massachusetts |
| ZIP/Postal code |
02142 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18644 |
Illumina HiSeq 2000 (Pseudomonas aeruginosa) |
|
| Samples (15)
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| Relations |
| BioProject |
PRJNA561292 |
| SRA |
SRP218964 |
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