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| Status |
Public on May 01, 2020 |
| Title |
Expression data from ileum samples from FADD IEC-KO (intestinal epithelial cell-knock out) and CASP8 IEC-KO mice in combination with different genetic mutations (Zbp1 -/-, Mlkl -/-, Ripk3 IEC-KO) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
FADD-IEC KO and CASP8 IEC-KO mice spontaneously develop chronic ileitis charcterized by inflammatory gene expression. We characterized the role of MLKL, RIPK3, ZBP1, in the upregulation of inlflammatory genes in these mice.
We used microarray to study the effect of MLKL, RIPK3 and ZBP1 on the gene expression profile in FADD IEC-KO and/or CASP8 IEC-KO mice and detect effects on specific inflammatory genes.
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| Overall design |
ileum samples were collected from 10-12 week old mice for RNA extraction and subsequent microarray analysis.
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| Contributor(s) |
Schwarzer R, Pasparakis M |
| Citation(s) |
32362323 |
| |
| Submission date |
Sep 11, 2019 |
| Last update date |
Jul 31, 2020 |
| Contact name |
Manolis Pasparakis |
| E-mail(s) |
pasparakis@uni-koeln.de
|
| Organization name |
University of Cologne
|
| Department |
Institute for Genetics
|
| Lab |
Pasparakis Lab
|
| Street address |
Joseph Stelzmann Strasse, 26
|
| City |
Cologne |
| State/province |
NRW |
| ZIP/Postal code |
50931 |
| Country |
Germany |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (45)
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| Relations |
| BioProject |
PRJNA565002 |
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