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Status |
Public on Dec 10, 2019 |
Title |
Transcriptome data from human endocrine cells recovered from mouse grafts with pre-engraftment controls |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
We examined the transcriptomes of alpha and beta cells recovered from mouse sub-renal capsule grafts of human islets as compared to alpha and beta cells from the same islet preps pre-engraftment. We found that after three to four weeks in the graft the human islets were still glucose responsive, secreting insulin following glucose challenge. In addition, gene expression was largely unchanged from the pre-engraftment control samples.
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Overall design |
Bulk and single-cell RNA-Seq analysis of human endocrine cells recovered from mouse engraftment
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Web link |
https://doi.org/10.1096/fj.201901022RR
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Contributor(s) |
Redick SD, Leehy L, Rittenhouse AR, Blodgett DM, Derr AG, Kucukural A, Garber MG, Shultz LD, Greiner DL, Wang JP, Harlan DM, Bortell R, Jurczyk A |
Citation(s) |
31914605 |
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Submission date |
Oct 11, 2019 |
Last update date |
Jan 13, 2020 |
Contact name |
Alan G Derr |
E-mail(s) |
alan.derr@umassmed.edu
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Organization name |
University of Massachusetts Medical School
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Department |
Program in Bioinformatics and Integrative Biology
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Lab |
Garber Lab
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Street address |
55 Lake Ave North
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City |
Worcester |
State/province |
Massachusetts |
ZIP/Postal code |
01655 |
Country |
USA |
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Platforms (1) |
GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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Samples (15)
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Relations |
BioProject |
PRJNA577039 |
SRA |
SRP225174 |