|
| Status |
Public on Oct 09, 2020 |
| Title |
A pathogen-specific 4mC methyltransferase is critical for epigenetic regulation and virulence of Leptospira interrogans |
| Organism |
Leptospira interrogans serovar Manilae |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Transcriptome analysis of a mutant in an orphan methyltranferase revealed global transcriptional regulation of 100 differentially expressed genes.
|
| |
|
| Overall design |
We used RNA-seq to compare the transcriptomes of wild-type L. interrogans with that of the lomA mutant and complemented strains under ideal culture conditions at mid-log phase.
|
| |
|
| Contributor(s) |
Gaultney RA, Vincent AT, Lorioux C, Coppee J, Sismeiro O, Varet H, Legendre R, Veyrier FJ, Picardeau M |
| Citation(s) |
33301041 |
| |
| Submission date |
Oct 15, 2019 |
| Last update date |
Dec 15, 2020 |
| Contact name |
Rachel Legendre |
| E-mail(s) |
rachel.legendre@pasteur.fr
|
| Organization name |
Institut Pasteur
|
| Department |
Research and Resource Center for Scientific Informatics
|
| Lab |
Hub of Bioinformatics and Biostatistics
|
| Street address |
28, rue du docteur Roux
|
| City |
Paris |
| ZIP/Postal code |
75724 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL21582 |
Illumina HiSeq 2500 (Leptospira interrogans serovar Manilae) |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA577724 |
| SRA |
SRP225811 |
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