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Series GSE138932 Query DataSets for GSE138932
Status Public on Apr 03, 2020
Title RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we determined transcriptional changes in Th1 cells upon deletion of the cofactor NCOR1.
Overall design mRNA expression profiles of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells were generated by deep sequencing
Contributor(s) Hainberger D, Ellmeier W
Citation(s) 32318068
Submission date Oct 16, 2019
Last update date Apr 27, 2020
Contact name Wilfried Ellmeier
Organization name Medical University of Vienna
Department Institute of Immunology
Street address Lazarettgase 19
City Vienna
ZIP/Postal code 1030
Country Austria
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (6)
GSM4123846 Th1_WT1 (RNA-seq)
GSM4123847 Th1_WT2 (RNA-seq)
GSM4123848 Th1_WT3 (RNA-seq)
This SubSeries is part of SuperSeries:
GSE138934 Role of NCOR1 in CD4+ T cells
BioProject PRJNA577837
SRA SRP225857

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Supplementary file Size Download File type/resource
GSE138932_RAW.tar 10.3 Mb (http)(custom) TAR (of TSV)
GSE138932_rnaseq_cuffdiff_genes_fpkm_replicates_Naive_Th1_Th17.tsv.gz 3.2 Mb (ftp)(http) TSV
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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