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| Status |
Public on Apr 03, 2020 |
| Title |
RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we determined transcriptional changes in Th1 cells upon deletion of the cofactor NCOR1.
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| Overall design |
mRNA expression profiles of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells were generated by deep sequencing
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| Contributor(s) |
Hainberger D, Ellmeier W |
| Citation(s) |
32318068 |
|
https://doi.org/10.3389/fimmu.2020.00579
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| |
| Submission date |
Oct 16, 2019 |
| Last update date |
Apr 27, 2020 |
| Contact name |
Wilfried Ellmeier |
| E-mail(s) |
wilfried.ellmeier@meduniwien.ac.at
|
| Organization name |
Medical University of Vienna
|
| Department |
Institute of Immunology
|
| Street address |
Lazarettgase 19
|
| City |
Vienna |
| ZIP/Postal code |
1030 |
| Country |
Austria |
| |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA577837 |
| SRA |
SRP225857 |
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