 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Nov 26, 2019 |
| Title |
Pharmacological activation of pyruvate kinase M2 (PKM2) inhibits CD4+ T cell pathogenicity and suppresses autoimmunity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 controls macrophage metabolic remodeling in inflammation, but its role in T cell biology is poorly understood. These results show that TEPP-46, an activator of PKM2, reduces CD4+ T cell activation, proliferation, and cytokine production by inhibiting essential signaling pathways and preventing glycolysis.
|
| |
|
| Overall design |
RNA-Seq was performed on resting or activated CD4+ T cells treated with or without the PKM2 activator TEPP-46.
|
| |
|
| Contributor(s) |
Angiari S, Runtsch MC, Sutton CE, Palsson-McDermott E, Kelly B, Rana N, Kane H, Papadopoulou G, Pearce EL, Mills KH, O'Neill LA |
| Citation(s) |
31761564 |
| |
| Submission date |
Oct 25, 2019 |
| Last update date |
Feb 18, 2020 |
| Contact name |
Immunometabolism Department |
| E-mail(s) |
jcurti29@jhmi.edu
|
| Organization name |
Johns Hopkins University
|
| Department |
Immunometabolism
|
| Street address |
1650 Orleans Street
|
| City |
Baltimore |
| State/province |
Maryland |
| ZIP/Postal code |
21287 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA579507 |
| SRA |
SRP226977 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE139378_Raw_Read_Count_Matrix.txt.gz |
401.5 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...