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Series GSE139378 Query DataSets for GSE139378
Status Public on Nov 26, 2019
Title Pharmacological activation of pyruvate kinase M2 (PKM2) inhibits CD4+ T cell pathogenicity and suppresses autoimmunity
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 controls macrophage metabolic remodeling in inflammation, but its role in T cell biology is poorly understood. These results show that TEPP-46, an activator of PKM2, reduces CD4+ T cell activation, proliferation, and cytokine production by inhibiting essential signaling pathways and preventing glycolysis.
Overall design RNA-Seq was performed on resting or activated CD4+ T cells treated with or without the PKM2 activator TEPP-46.
Contributor(s) Angiari S, Runtsch MC, Sutton CE, Palsson-McDermott E, Kelly B, Rana N, Kane H, Papadopoulou G, Pearce EL, Mills KH, O'Neill LA
Citation(s) 31761564
Submission date Oct 25, 2019
Last update date Feb 18, 2020
Contact name Immunometabolism Department
Organization name Johns Hopkins University
Department Immunometabolism
Street address 1650 Orleans Street
City Baltimore
State/province Maryland
ZIP/Postal code 21287
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (9)
GSM4139643 Resting_1
GSM4139644 Resting_4
GSM4139645 Resting_5
BioProject PRJNA579507
SRA SRP226977

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Supplementary file Size Download File type/resource
GSE139378_Raw_Read_Count_Matrix.txt.gz 401.5 Kb (ftp)(http) TXT
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