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Series GSE139383 Query DataSets for GSE139383
Status Public on Oct 26, 2019
Title Expression data from rat vocal fold at different periods after vocal fold injury
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Vocal cord healing is a dynamic process, and many genes and proteins are involved, which play varying roles at different regeneration stages after injury. Previous studies have shown that inflammatory responses occur at the early stage of vocal cord injury, where the fibroblasts proliferate exuberantly with intensive secretion and deposition of ECM. These activities reach the peak at 3-7 days and their intensity begins to decline 15 days later. A study based on the dermal system has shown that ECM remodeling during the repair of injury can last for several months. However, few studies have been conducted as to the dynamic changes of gene expressions and signaling pathway during the healing process of vocal cord injury. Plotting these changes will facilitate the understanding about the physiological changes during healing and the identification of key time points and target genes in fibrosis formation.
 
Overall design 20 animals were randomly divided into 4 experimental groups based on time of sacrifice: uninjured control, and 1, 4 and 8 weeks after injury. Following sacrifice, the larynx was harvested, and the bilateral vocal folds were dissected under magnification.
 
Contributor(s) Wang H, Xu W
Citation(s) 32667625
Submission date Oct 25, 2019
Last update date Aug 03, 2020
Contact name 李 玉琳
Organization name Beijing Institute of Heart Lung and Blood Vessel Diseases
Street address 2 Anzhen Rd, Chaoyang District,
City Beijing
ZIP/Postal code 100029
Country China
 
Platforms (1)
GPL23040 [Clariom_S_Rat] Affymetrix Clariom S Assay, Rat (Includes Pico Assay)
Samples (20)
GSM4140273 Vocal fold, control_1
GSM4140274 Vocal fold, control_2
GSM4140275 Vocal fold, control_3
Relations
BioProject PRJNA579528

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139383_RAW.tar 18.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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