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Series GSE140495 Query DataSets for GSE140495
Status Public on Feb 04, 2020
Title In vivo CRISPR screens reveal NOTCH regulators suppressing Head and Neck Squamous Cell Carcinoma in mice [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In most cancers, only a few genes are mutated at high frequencies, while the vast majority are mutated at low frequencies. The functions of these recurrent but infrequent ‘long-tail’ mutations remain largely elusive. Here, we develop in vivo CRISPR screens to assess the transforming potential of 484 long-tail genes in human Head and Neck Squamous Cell 5 Carcinoma (HNSCC).
Overall design Analyzed differential expression between Adam10, Ajuba KO vs. the WT primary mouse keratinocytes.
Contributor(s) Loganathan SK, Malik AA, Schramek D
Citation(s) 32165588
Submission date Nov 15, 2019
Last update date May 22, 2021
Contact name Daniel Schramek
Organization name Lunenfeld- Tanenbaum Research Institute
Lab Schramek Lab
Street address 600 University Ave, Room 1080
City Toronto
State/province ON
ZIP/Postal code M5G 1X5
Country Canada
Platforms (2)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (21)
GSM4171586 Control_sgLacZ_p4_Rep1
GSM4171587 Control_sgLacZ_p4_Rep2
GSM4171588 sgAdam10_p4_Rep1
This SubSeries is part of SuperSeries:
GSE140497 In vivo CRISPR screens reveal NOTCH regulators suppressing Head and Neck Squamous Cell Carcinoma in mice
BioProject PRJNA589896
SRA SRP230218

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140495_Tumors_Adam10_KO_deseq2.xlsx 10.8 Mb (ftp)(http) XLSX
GSE140495_p4_Adam10_KO_deseq2.xlsx 7.0 Mb (ftp)(http) XLSX
GSE140495_p4_sgAdam10_deseq2.xlsx 2.5 Mb (ftp)(http) XLSX
GSE140495_p4_sgAjuba_deseq2.xlsx 2.3 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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