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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 01, 2021 |
| Title |
Estrogen Drives Melanocortin Neurons To Reduce Sedentary Behavior |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Estrogen depletion in both rodents and humans leads to inactivity, unhealthy fat accumulation, and metabolic syndrome, underscoring the conserved metabolic benefits of estrogen signaling that inevitably decline with aging. Here, we uncover a hypothalamic node that integrates estrogen and melanocortin-4 receptor (MC4R) signaling to drive episodic bursts in activity prior to ovulation. Skirting the estrogen-dependent gating of this node by CRISPR activation of Mc4r reduces sedentary behavior long-term in both males and females. Our findings expand the impact of MC4R signaling beyond food intake regulation and rationalize reported sex-differences in melanocortin signaling including increased disease severity for women with MC4R-insuffciency. This newly identified hormone-dependent activity node illustrates the potency of estrogen in maintaining an active lifestyle.
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| Overall design |
Analysis of ERĪ± binding in adult mouse limbic tissue by CUT&RUN
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| Contributor(s) |
Krause WC, Rodriguez R, Gegenhuber B, Matharu N, Rodriguez AN, Padilla AM, Herber CB, Correa SM, Ahituv N, Tollkuhn J, Ingraham HA |
| Citation(s) |
34646010 |
| Submission date |
Dec 04, 2019 |
| Last update date |
Nov 10, 2021 |
| Contact name |
Bruno Gegenhuber |
| E-mail(s) |
bruno_gegenhuber@hms.harvard.edu
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| Organization name |
Harvard Medical School
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| Department |
Neurobiology
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| Street address |
220 Longwood Ave
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA593491 |
| SRA |
SRP234697 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE141434_RAW.tar |
306.4 Mb |
(http)(custom) |
TAR (of BED, BW) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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