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| Status |
Public on Aug 31, 2021 |
| Title |
Transcriptional profilling of Plasmodium falciparum parasites with disrupted PfNot1.1 (PF3D7_1103800) or PfNot1.2 (PF3D7_1417200) |
| Organism |
Plasmodium falciparum |
| Experiment type |
Expression profiling by array
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| Summary |
The study aims to investigate functions of two PfNOT1 paralogues in regulating gene expression in the malaria parasite, P. falciparum.
To achieve this goal, the transcriptional profilling of parasites lacking PfNot1.1 or PfNOT1.2 was analyzed by microarray technology.
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| Overall design |
The endogenous PfNot1.1 was disrupted and PfNot1.2 was conditionally knocked down. Transcriptional profiling of the mutated parasites and the wildtype line was assessed at six timepoints across one parasite's intraerythrocytic life cycle.
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| Contributor(s) |
Liu Y, Bozdech Z, Featherstone M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Dec 18, 2019 |
| Last update date |
Sep 02, 2021 |
| Contact name |
Ying Liu |
| E-mail(s) |
yliu037@e.ntu.edu.sg
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| Phone |
84030462
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| Organization name |
Nanyang Technological University
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| Department |
School of Biological Sciences
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| Lab |
Prof. Zbynek Bozdech's lab
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| Street address |
60 Nanyang Drive
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| City |
Singapore |
| ZIP/Postal code |
637551 |
| Country |
Singapore |
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| Platforms (1) |
| GPL11248 |
ZB/SBS-NTU Plasmodium falciparum 3D7 11.4K v1.1 |
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| Samples (72)
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| GSM4224208 |
PfNot1.1 knockout, TP4, replicate 1 |
| GSM4224209 |
PfNot1.1 knockout, TP5, replicate 1 |
| GSM4224210 |
PfNot1.1 knockout, TP6, replicate 1 |
| GSM4224211 |
PfNot1.1 knockout, TP1, replicate 2 |
| GSM4224212 |
PfNot1.1 knockout, TP2, replicate 2 |
| GSM4224213 |
PfNot1.1 knockout, TP3, replicate 2 |
| GSM4224214 |
PfNot1.1 knockout, TP4, replicate 2 |
| GSM4224215 |
PfNot1.1 knockout, TP5, replicate 2 |
| GSM4224216 |
PfNot1.1 knockout, TP6, replicate 2 |
| GSM4224217 |
PfNot1.1 knockout, TP1, replicate 3 |
| GSM4224218 |
PfNot1.1 knockout, TP2, replicate 3 |
| GSM4224219 |
PfNot1.1 knockout, TP3, replicate 3 |
| GSM4224220 |
PfNot1.1 knockout, TP4, replicate 3 |
| GSM4224221 |
PfNot1.1 knockout, TP5, replicate 3 |
| GSM4224222 |
PfNot1.1 knockout, TP6, replicate 3 |
| GSM4224223 |
wildtype line for PfNot1.1 knockout, TP1, replicate 1 |
| GSM4224224 |
wildtype line for PfNot1.1 knockout, TP2, replicate 1 |
| GSM4224225 |
wildtype line for PfNot1.1 knockout, TP3, replicate 1 |
| GSM4224226 |
wildtype line for PfNot1.1 knockout, TP4, replicate 1 |
| GSM4224227 |
wildtype line for PfNot1.1 knockout, TP5, replicate 1 |
| GSM4224228 |
wildtype line for PfNot1.1 knockout, TP6, replicate 1 |
| GSM4224229 |
wildtype line for PfNot1.1 knockout, TP1, replicate 2 |
| GSM4224230 |
wildtype line for PfNot1.1 knockout, TP2, replicate 2 |
| GSM4224231 |
wildtype line for PfNot1.1 knockout, TP3, replicate 2 |
| GSM4224232 |
wildtype line for PfNot1.1 knockout, TP4, replicate 2 |
| GSM4224233 |
wildtype line for PfNot1.1 knockout, TP5, replicate 2 |
| GSM4224234 |
wildtype line for PfNot1.1 knockout, TP6, replicate 2 |
| GSM4224235 |
wildtype line for PfNot1.1 knockout, TP1, replicate 3 |
| GSM4224236 |
wildtype line for PfNot1.1 knockout, TP2, replicate 3 |
| GSM4224237 |
wildtype line for PfNot1.1 knockout, TP3, replicate 3 |
| GSM4224238 |
wildtype line for PfNot1.1 knockout, TP4, replicate 3 |
| GSM4224239 |
wildtype line for PfNot1.1 knockout, TP5, replicate 3 |
| GSM4224240 |
wildtype line for PfNot1.1 knockout, TP6, replicate 3 |
| GSM4224241 |
PfNot1.2 knockdown, TP1, replicate 1 |
| GSM4224242 |
PfNot1.2 knockdown, TP2, replicate 1 |
| GSM4224243 |
PfNot1.2 knockdown, TP3, replicate 1 |
| GSM4224244 |
PfNot1.2 knockdown, TP4, replicate 1 |
| GSM4224245 |
PfNot1.2 knockdown, TP5, replicate 1 |
| GSM4224246 |
PfNot1.2 knockdown, TP6, replicate 1 |
| GSM4224247 |
PfNot1.2 knockdown, TP1, replicate 2 |
| GSM4224248 |
PfNot1.2 knockdown, TP2, replicate 2 |
| GSM4224250 |
PfNot1.2 knockdown, TP3, replicate 2 |
| GSM4224251 |
PfNot1.2 knockdown, TP4, replicate 2 |
| GSM4224253 |
PfNot1.2 knockdown, TP5, replicate 2 |
| GSM4224254 |
PfNot1.2 knockdown, TP6, replicate 2 |
| GSM4224255 |
PfNot1.2 knockdown, TP1, replicate 3 |
| GSM4224256 |
PfNot1.2 knockdown, TP2, replicate 3 |
| GSM4224257 |
PfNot1.2 knockdown, TP3, replicate 3 |
| GSM4224258 |
PfNot1.2 knockdown, TP4, replicate 3 |
| GSM4224259 |
PfNot1.2 knockdown, TP5, replicate 3 |
| GSM4224260 |
PfNot1.2 knockdown, TP6, replicate 3 |
| GSM4224261 |
wildtype line for PfNot1.2 knockdown, TP1, replicate 1 |
| GSM4224262 |
wildtype line for PfNot1.2 knockdown, TP2, replicate 1 |
| GSM4224263 |
wildtype line for PfNot1.2 knockdown, TP3, replicate 1 |
| GSM4224264 |
wildtype line for PfNot1.2 knockdown, TP4, replicate 1 |
| GSM4224265 |
wildtype line for PfNot1.2 knockdown, TP5, replicate 1 |
| GSM4224266 |
wildtype line for PfNot1.2 knockdown, TP6, replicate 1 |
| GSM4224267 |
wildtype line for PfNot1.2 knockdown, TP1, replicate 2 |
| GSM4224268 |
wildtype line for PfNot1.2 knockdown, TP2, replicate 2 |
| GSM4224269 |
wildtype line for PfNot1.2 knockdown, TP3, replicate 2 |
| GSM4224270 |
wildtype line for PfNot1.2 knockdown, TP4, replicate 2 |
| GSM4224271 |
wildtype line for PfNot1.2 knockdown, TP5, replicate 2 |
| GSM4224272 |
wildtype line for PfNot1.2 knockdown, TP6, replicate 2 |
| GSM4224273 |
wildtype line for PfNot1.2 knockdown, TP1, replicate 3 |
| GSM4224274 |
wildtype line for PfNot1.2 knockdown, TP2, replicate 3 |
| GSM4224275 |
wildtype line for PfNot1.2 knockdown, TP3, replicate 3 |
| GSM4224276 |
wildtype line for PfNot1.2 knockdown, TP4, replicate 3 |
| GSM4224277 |
wildtype line for PfNot1.2 knockdown, TP5, replicate 3 |
| GSM4224278 |
wildtype line for PfNot1.2 knockdown, TP6, replicate 3 |
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| Relations |
| BioProject |
PRJNA596455 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE142275_RAW.tar |
87.8 Mb |
(http)(custom) |
TAR (of GPR) |
| Processed data included within Sample table |
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