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| Status |
Public on Jan 07, 2020 |
| Title |
Maternal weight affects placental DNA methylation of genes invovled in metabolic pathways in the common marmoset monkey (Callithrix jacchus) |
| Organism |
Callithrix jacchus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus, is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here, we report genome-wide DNAm from term marmoset placentas using reduced representation bisulfite sequencing. We identified 74 genes whose DNAm pattern is associated with maternal weight during gestation. These genes are predominantly involved in energy metabolism and homeostasis, including regulation of glycolytic and lipid metabolic processes pathways.
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| Overall design |
17 samples ran in duplicate. The sample description indicates the location and the placental disc that each sample was obtained from
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| Contributor(s) |
Narapareddy L, Wildman DE, Armstrong DL, Weckle A, Bell AF, Patil CL, Tardif SD, Ross CN, Rutherford JN |
| Citation(s) |
32020652 |
| |
| Submission date |
Jan 06, 2020 |
| Last update date |
Apr 08, 2020 |
| Contact name |
Derek Wildman |
| Organization name |
University of South Florida
|
| Street address |
3720 Spectrum Blvd
|
| City |
Tampa |
| State/province |
FL |
| ZIP/Postal code |
33612 |
| Country |
USA |
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| Platforms (1) |
| GPL26566 |
Illumina HiSeq 4000 (Callithrix jacchus) |
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| Samples (34)
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| Relations |
| BioProject |
PRJNA599182 |
| SRA |
SRP239604 |
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