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| Status |
Public on Jun 23, 2020 |
| Title |
Context-dependent IL-1 mRNA-destabilization by TTP prevents dysregulation of immune homeostasis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report that TTP exhibits context-dependent target destabilisation and that such context-defined mRNA decay is essential for maintaining steady state IL-1 levels in the physiological range
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| Overall design |
mRNA profiles of untreated and LPS-stimulated WT and TTP-/- murine bone marrow-derived dendritic cells
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| Contributor(s) |
Sneezum L, Kovarik P |
| Citation(s) |
32733464 |
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| Submission date |
Jan 07, 2020 |
| Last update date |
Aug 03, 2020 |
| Contact name |
Pavel Kovarik |
| E-mail(s) |
pavel.kovarik@univie.ac.at
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| Organization name |
University of Vienna
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| Department |
Max Perutz Labs
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| Street address |
Dr.-Bohr-Gasse 9/4
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| City |
Wien |
| ZIP/Postal code |
1030 |
| Country |
Austria |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (24)
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| GSM4254252 |
TTP KO, 0h, replicate 1 |
| GSM4254253 |
TTP KO, 0h, replicate 2 |
| GSM4254254 |
TTP KO, 0h, replicate 3 |
| GSM4254255 |
Wild type, 3h, replicate 1 |
| GSM4254256 |
Wild type, 3h, replicate 2 |
| GSM4254257 |
Wild type, 3h, replicate 3 |
| GSM4254258 |
TTP KO, 3h, replicate 1 |
| GSM4254259 |
TTP KO, 3h, replicate 2 |
| GSM4254260 |
TTP KO, 3h, replicate 3 |
| GSM4254261 |
Wild type, 6h, replicate 1 |
| GSM4254262 |
Wild type, 6h, replicate 2 |
| GSM4254263 |
Wild type, 6h, replicate 3 |
| GSM4254264 |
TTP KO, 6h, replicate 1 |
| GSM4254265 |
TTP KO, 6h, replicate 2 |
| GSM4254266 |
TTP KO, 6h, replicate 3 |
| GSM4254267 |
Wild type, 9h, replicate 1 |
| GSM4254268 |
Wild type, 9h, replicate 2 |
| GSM4254269 |
Wild type, 9h, replicate 3 |
| GSM4254270 |
TTP KO, 9h, replicate 1 |
| GSM4254271 |
TTP KO, 9h, replicate 2 |
| GSM4254272 |
TTP KO, 9h, replicate 3 |
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| Relations |
| BioProject |
PRJNA599384 |
| SRA |
SRP239817 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE143241_0h.xlsx |
3.6 Mb |
(ftp)(http) |
XLSX |
| GSE143241_3h.xlsx |
3.5 Mb |
(ftp)(http) |
XLSX |
| GSE143241_6h.xlsx |
3.4 Mb |
(ftp)(http) |
XLSX |
| GSE143241_9h.xlsx |
3.4 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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