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| Status |
Public on May 25, 2020 |
| Title |
Gene expression profiling of blood of Ebola virus disease survivors and Healthy donors by Next Generation Sequencing |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Clinical follow-up of Ebola virus disease (EVD) survivors revealed a persistence of clinical symptoms and higher risk of mortality. Long-term analyses of the immune and inflammatory profiles of EVD survivors are currently lacking. Here, we evaluate gene expression profiles in 26 Guinean Ebola virus disease survivors (EBOV_S) and 33 Healthy donnors (HD). We show a persistent increase of several biomarkers of inflammation, immune activation and gut tissue damage in EBOV_S compared to healthy donors living in the same area. Gene expression profiling in blood revealed a significant enrichment in genes associated with antiviral responses in EBOV_S.
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| |
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| Overall design |
Analysis of whole-blood gene expression profiles of 26 Ebola virus disease survivors and 33 Healthy donnors
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| |
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| Contributor(s) |
Wiedemann A, Hocini H, Lefebvre C, Lacabaratz C, Lévy Y, Krueger M, Durand M, Thiébaut R |
| Citation(s) |
32709840 |
| |
| Submission date |
Jan 13, 2020 |
| Last update date |
Aug 03, 2020 |
| Contact name |
cecile lefebvre |
| E-mail(s) |
cecile.lefebvre@inserm.fr
|
| Organization name |
INSERM U955_VRI
|
| Street address |
51 Avenue du Marechal De Lattre de Tassigny
|
| City |
Créteil |
| ZIP/Postal code |
94810 |
| Country |
France |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (59)
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| Relations |
| BioProject |
PRJNA600939 |
| SRA |
SRP241739 |
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