|
| Status |
Public on Jan 12, 2023 |
| Title |
Characterization of the mechansims involved in resistance to EGFR inhibitors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We generated patient cSCC-derived xenografts (cSCC-PDXs) that recapitulate the histopathologic and molecular features of parental patient samples. Response to gefitinib treatment was tested in four independent models. cSCC34-PDXs showed intrinsic resistance to gefitinib, whereas three models (cSCC10-PDXs, cSCC16-PDXs and cSCC24-PDXs) initially showed a strong response to gefitinib, but acquired resistance after long-term treatment. RNA sequencing analysis were performed in matched untreated and gefitinib-resistant cSCC-PDXs to determine mechanisms behind gefitinib resistance.
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| |
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| Overall design |
RNA sequencing of control (treated with vehicle solution) cSCC-PDXs vs gefitinib-resistant cSCC-PDXs from four different patients
|
| |
|
| Contributor(s) |
Muñoz P, Peguera AB, Palomero L |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 13, 2020 |
| Last update date |
Jan 12, 2023 |
| Contact name |
Purificación Muñoz |
| E-mail(s) |
p.munoz@idibell.cat
|
| Organization name |
IDIBELL
|
| Street address |
Av Gran Vía de L'Hospitalet 199-203
|
| City |
Barcelona |
| ZIP/Postal code |
08908 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (24)
|
|
| Relations |
| BioProject |
PRJNA600989 |
| SRA |
SRP241820 |
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