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Series GSE144086 Query DataSets for GSE144086
Status Public on Jan 23, 2020
Title Goat's milk feeding enhances innate and adaptive immunities and alleviates allergen-induced airway inflammation in offspring mice
Platform organism metagenomes
Sample organism Mus musculus
Experiment type Genome variation profiling by array
Summary Goat’s milk (GM), as compared to Cow’s milk (CM), is easier for human to digest and absorb. GM feeding can improve colic, minor digestive disorders, asthma or eczema in infants. It has been demonstrated that GM have antioxidant and anti-inflammatory effects. Whether GM consumed in pregnant mothers has any immune-modulating effects on their newborns is still unclear. In this study, we used pregnant mothers and their offspring mice to verify this hypothesis.
we collected feces of offspring before allergen sensitization (day 0) and two days after i.t. allergen challenge (day 16). Detection of cDNA of feces using Applied Biosystems™ Axiom™ Microbiome Array found the phyla of Bacteroidia, Clostridia, Flavobacteriia, Deferribacteres, Verrucomicrobiae and Gammaproteobacteria as well as some unclassified viruses. Comparison in ratio of Firmicutes to Bacteroidetes (F/B ratio), water-fed (W0) group had higher F/B ratio (0.79) than GM-fed (G0) (0.50) and CM-fed (C0) group (0.54) at Day 0. After HDM allergen sensitization and challenge, there was a remarkable increase of F/B ratio in water-fed mice (0.63 in WN vs. 0.84 in WA), while there was no change of F/B ratio in GM-fed (GN vs. GA) and CM-fed mice (CN vs. CA)
 
Overall design 44 total sample were analyzed
 
Contributor(s) Kao H, Wang Y, Tzseng H, Shih-Hsin Wu L, Tsai H, Hsieh M, Chen P, Kuo W, Liu L, Liu Z, Wang J
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Submission date Jan 22, 2020
Last update date Jan 26, 2020
Contact name Jiu Yao Wang
E-mail(s) a122@mail.ncku.edu.tw
Organization name Nation Cheng Kung University
Street address No.138,Sheng Li Road,Tainan
City Tainan
ZIP/Postal code Taiwan 704, R.O.C.
Country Taiwan
 
Platforms (1)
GPL28028 [Axiom_MDA] Applied Biosystems (Affymetrix) Axiom Microbiome Array
Samples (44)
GSM4279711 stool at D0, cow's milk, asthma,rep1
GSM4279712 stool at D0, cow's milk, asthma,rep2
GSM4279713 stool at D0, cow's milk, naïve,rep1
Relations
BioProject PRJNA602719

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE144086_RAW.tar 376.6 Mb (http)(custom) TAR (of CEL, TXT)
Processed data provided as supplementary file

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