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| Status |
Public on Apr 01, 2021 |
| Title |
Endotype of Allergic Asthma with Airway Obstruction in Urban Children |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In the first decade of life, high-asthma risk urban children develop stable phenotypes of respiratory health versus disease that link early life environmental exposures to childhood allergic sensitization and asthma. Moreover, unique patterns of nasal gene expression demonstrate how specific molecular pathways underlie distinct respiratory phenotypes, including allergic and non-allergic asthma.
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| Overall design |
URECA is a high risk asthma birth cohort study. These samples are nasal brush samples taken at age 11. They were used to identify airway gene expression patterns that associate with clinical phenotypes over time.
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| Contributor(s) |
Altman MC, Ramratnam S, Jackson DJ, Presnell SR, Gergen PJ, Bacharier LB, O'Connor GT, Kattan M, Wood RA, Calatroni A, Visness CM, Gern JE |
| Citation(s) |
33713771, 35606880, 36754293 |
| |
| Submission date |
Feb 18, 2020 |
| Last update date |
May 17, 2024 |
| Contact name |
Stephanie Osmond |
| E-mail(s) |
sosmond@benaroyaresearch.org
|
| Organization name |
Benaroya Research Institute
|
| Street address |
1201 9th Ave
|
| City |
Seattle, |
| State/province |
WA |
| ZIP/Postal code |
98101 |
| Country |
USA |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (353)
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| Relations |
| BioProject |
PRJNA607333 |
| SRA |
SRP249918 |
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