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Series GSE145732 Query DataSets for GSE145732
Status Public on Feb 22, 2020
Title Pathogen-pathogen interactions, a way to soothe virulence?
Organisms Klebsiella oxytoca; Staphylococcus aureus; Bacillus thuringiensis
Experiment type Expression profiling by high throughput sequencing
Summary In planktonic and biofilm mimicking environments, the staphyloccocal transcriptome in t111+t13595 co-cultures showed significant upregulation of genes related to virulence factors contrary to those co-cultures with B. thuringiesis and K. oxytoca. In the biofilm polymicrobial environment, S. aureus transcriptome shows extensive downregulation of gene expression. The animal model co-infection with S. aureus and K. oxytoca proved to be less virulent than when infected only with S. aureus alone, or K. oxytoca alone where higher infection and mortality rates were observed.
Overall design Two Staphylococcus aureus strains, one Bacillus thuringiensis, and one Klebsiella oxytoca strains. Twenty three different conditions.
Contributor(s) García-Pérez AN, van Dijl JM, de Jong A
Citation(s) 29233035
Submission date Feb 21, 2020
Last update date May 25, 2020
Contact name Anne de Jong
Phone +31 50 363 2047
Organization name university of Groningen
Department Molecular Genetics
Street address Nijenborgh 7
City Groningen
ZIP/Postal code 9747 AG
Country Netherlands
Platforms (3)
GPL20673 Ion Torrent Proton (Staphylococcus aureus)
GPL28182 Ion Torrent Proton (Bacillus thuringiensis)
GPL28183 Ion Torrent Proton (Klebsiella oxytoca)
Samples (64)
GSM4331669 Bt
GSM4331670 Ko
GSM4331671 mix_Bt
BioProject PRJNA608015
SRA SRP250330

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Supplementary file Size Download File type/resource
GSE145732_RAW.tar 8.5 Mb (http)(custom) TAR (of RPKM)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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