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Series GSE146053 Query DataSets for GSE146053
Status Public on Jun 01, 2020
Title A negative reciprocal regulatory axis between cyclin D1 and HNF4α modulates cell cycle progression and metabolism in the liver
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary This study examines the regulation of HNF4a by cyclin D1 in hepatic cell lines and mouse liver.
Overall design Three different cell lines were treated with control of cyclin D1 siRNA, followed by RNA-seq. Mice had transduction of cyclin D1 (or a truncation mutant called cyclin D1-RD) into the liver using recombinant adenovirus, followed by HNF4a ChIP-seq.
Contributor(s) Wu H, Reizel Y, Wang YJ, Lapiro JL, Kren BT, Schug J, Rao S, Morgan A, Herman A, Shekels LL, Rassette M, Lane AN, Cassel T, Fan TM, Manivel JC, Gunewardena SS, Apte U, Sicinski P, Kaestner K, Albrecht JH
Citation(s) 32631996
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 DK054921 Cyclin D1/CDK4 Complex in Hepatocyte Proliferation UNIVERSITY OF MINNESOTA JEFFREY H ALBRECHT
Submission date Feb 27, 2020
Last update date Aug 31, 2020
Contact name Jeffrey H Albrecht
Organization name University of Minnesota
Department Medicine - Gastroenterology
Street address One Veterans Drive
City Miinneapolis
State/province MN
ZIP/Postal code 55417
Country USA
Platforms (3)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (198)
GSM4363586 (-)_siC_1 FGC1198_s_1
GSM4363587 (-)_siC_1 FGC1198_s_2
GSM4363588 (-)_siC_1 FGC1198_s_3
BioProject PRJNA609166
SRA SRP251094

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE146053_ADV-CyclinD1-FLAG-HA_HNF4a_ChIP_Rep1.peaks.txt.gz 838.5 Kb (ftp)(http) TXT
GSE146053_ADV-CyclinD1-FLAG-HA_HNF4a_ChIP_Rep2.peaks.txt.gz 1.3 Mb (ftp)(http) TXT
GSE146053_ADV-CyclinD1-FLAG-HA_HNF4a_ChIP_Rep3.peaks.txt.gz 753.8 Kb (ftp)(http) TXT
GSE146053_ADV-D1-RD-FLAG_HNF4a_ChIP_Rep1.peaks.txt.gz 955.3 Kb (ftp)(http) TXT
GSE146053_ADV-D1-RD-FLAG_HNF4a_ChIP_Rep2.peaks.txt.gz 1.2 Mb (ftp)(http) TXT
GSE146053_ADV-D1-RD-FLAG_HNF4a_ChIP_Rep3.peaks.txt.gz 1016.2 Kb (ftp)(http) TXT
GSE146053_Control-ADV_HNF4a_ChIP_Rep1.peaks.txt.gz 1.3 Mb (ftp)(http) TXT
GSE146053_Control-ADV_HNF4a_ChIP_Rep2.peaks.txt.gz 1.2 Mb (ftp)(http) TXT
GSE146053_Control-ADV_HNF4a_ChIP_Rep3.peaks.txt.gz 1.2 Mb (ftp)(http) TXT
GSE146053_RawTranscriptCounts_AML12.xls.gz 2.5 Mb (ftp)(http) XLS
GSE146053_RawTranscriptCounts_HEPG2.xls.gz 1.8 Mb (ftp)(http) XLS
GSE146053_RawTranscriptCounts_SkHep1.xls.gz 2.8 Mb (ftp)(http) XLS
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