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| Status |
Public on Oct 06, 2021 |
| Title |
Epigenetic landscape of Mammalian Brain M1 by Single Nucleus Methylation Sequencing [MM_M1] |
| Organism |
Callithrix jacchus |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
Illustrating the cellular architecture of the mammalian brain is critical to understanding its diverse functions and complex animal behaviors. Single nucleus methylation sequencing was applied to M1 regions of human and mouse brains. we identified distinct cell clusters and formed them in a hierarchical taxonomy. These clusters include known primary brain cell types and possible sub-types. We use these data to identify the epigenomic characteristics and to define specific regulatory elements for each cell cluster.
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| Overall design |
Apply snmC-seq2 to brain M1 regions to identify epigenomic landcape of the adult human and marmoset brains
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| Contributor(s) |
Tian W, Liu H, Luo C, Bartlett A, Krienen FM, Hodge RD, Lucero J, Nery JR, Rivkin A, Aldridge A, Castanon R, Chen H, Niu S, Behrens MM, Feng G, Lein E, Ecker JR |
| Citation(s) |
34616062 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| U01 MH121282 |
Epigenomic cell-type classification and regulatory element identification in the human brain |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
Joseph R Ecker |
| HHMI_Ecker_J |
Investigator |
Ecker, Joseph R. |
Joseph R. Ecker |
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| |
| Submission date |
Mar 08, 2020 |
| Last update date |
Jan 05, 2022 |
| Contact name |
Joseph R Ecker |
| E-mail(s) |
ecker@salk.edu
|
| Phone |
8584534100
|
| Organization name |
HHMI-Salk-Institute
|
| Department |
Genomic Analysis Laboratory
|
| Lab |
Ecker lab
|
| Street address |
10010 North Torrey Pines Road
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL28240 |
Illumina NovaSeq 6000 (Callithrix jacchus) |
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| Samples (3047)
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| Relations |
| BioProject |
PRJNA611534 |
| SRA |
SRP252051 |
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