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| Status |
Public on Mar 21, 2020 |
| Title |
Whole transcriptomic analysis of mechanisms of tolerance and resistance to chlorhexidine in carbapenemase-producing Klebsiella pneumoniae clinical strains |
| Organism |
Klebsiella pneumoniae |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The increasing resistence and/or bacterial tolerance to bactericides, such as chlorhexidine, causes worrisome public health problems. Using transcriptomical and microbiological studies, we analysed the molecular mechanisms associated with the adaptation to chlorhexidine in two carbapenemase-producing strains of Klebsiella pneumoniae belonging ST258-KPC3 and ST846-OXA48.
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| Overall design |
In this study, we analized four clinical strains of Klebsiella pneumoniae producing carpabenemase, two of them adapted to chlorhexidine (ST258-KPC3CA and ST846-OXA48CA) and their respective controls (ST258-KPC3 and ST846-OXA48). For each strain there are four replicate. Statical analysis by DESeq2 and EdgeR.
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| Contributor(s) |
Bleriot I, Blasco L, Delgado M, Gual de Torella A, Ambroa A, Fernandez-García L, Lopez M, Pacios O, Oteo J, Pascual A, Bou G, Fernandez-Cuenca F, Tomas M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 20, 2020 |
| Last update date |
Jun 12, 2020 |
| Contact name |
Maria Tomas-Carmona |
| E-mail(s) |
ma.del.mar.tomas.carmona@sergas.es
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| Organization name |
Instituto de Investigación Biomédica de A Coruña (INIBIC) / Complexo Hospitalario Universitario de A Coruña (CHUAC)
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| Department |
Microbiology Department
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| Street address |
As Xubias, 84
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| City |
A Coruña |
| ZIP/Postal code |
15006 |
| Country |
Spain |
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| Platforms (1) |
| GPL28296 |
Ion Torrent PGM (Klebsiella pneumoniae) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA613720 |
| SRA |
SRP253525 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE147316_G-DESeq2-test-sum_padj_005-ST258-KPC3-3-MT-vs-C.csv.gz |
279.9 Kb |
(ftp)(http) |
CSV |
| GSE147316_G-DESeq2-test-sum_padj_005-ST846-OXA48-3-MT-vs-C.csv.gz |
268.1 Kb |
(ftp)(http) |
CSV |
| GSE147316_G-sigDownReg-deseq_FDR0.05-ST258-KPC3.csv.gz |
141.8 Kb |
(ftp)(http) |
CSV |
| GSE147316_G-sigDownReg-deseq_FDR0.05-ST846-OXA48.csv.gz |
31.5 Kb |
(ftp)(http) |
CSV |
| GSE147316_G-sigUpReg-deseq_FDR0.05-ST258-KPC3.csv.gz |
116.5 Kb |
(ftp)(http) |
CSV |
| GSE147316_G-sigUpReg-deseq_FDR0.05-ST846-OXA48.csv.gz |
35.6 Kb |
(ftp)(http) |
CSV |
| GSE147316_Resumen_ST846-OXA48_ST258-KPC3_DESEQ2.xlsx |
5.2 Mb |
(ftp)(http) |
XLSX |
| GSE147316_ST258-KPC3-DESEQ2.csv.gz |
1.2 Mb |
(ftp)(http) |
CSV |
| GSE147316_ST846-OXA48-DESEQ2.csv.gz |
1.2 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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