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| Status |
Public on Jun 23, 2020 |
| Title |
Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced rat septic shock model [circRNA] |
| Organism |
Rattus norvegicus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Septic shock is the most common cause of death in intensive care units. The aim of this study is to investigate the role of circular RNA (circRNA) and mRNA expression profiles and functional networks in aortic tissue of septic shock.
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| Overall design |
Septic shock model in rats was established by intraperitoneal injection of lipopolysaccharide (LPS). High-throughput sequencing and bioinformatics analysis were performed on aortic tissue to identify differentially expressed (DE)circRNAs, which were validated by qRT-PCR. We performed bioinformatics analysis and constructed circRNA-mRNA and circRNA-miRNA-mRNA networks to investigate mechanisms related to biological functions and signaling pathways. Then, functional and pathway enrichment analyses were performed.
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| Contributor(s) |
Nie M, Han Y, Shen Z, Xie H |
| Citation(s) |
32452125 |
| |
| Submission date |
Mar 30, 2020 |
| Last update date |
Jun 23, 2020 |
| Contact name |
Jinghua Yang |
| E-mail(s) |
yangjh@xy-data.net
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| Organization name |
Beijing Zhiyun data technology co. LTD
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| Street address |
32 North Third Ring Road West, Haidian District, Beijing
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| City |
Beijing |
| ZIP/Postal code |
100098 |
| Country |
China |
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| Platforms (1) |
| GPL21828 |
082778 Arraystar Rat CircRNA microarray V1 |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE147775 |
Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced rat septic shock model |
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| Relations |
| BioProject |
PRJNA616338 |
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