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| Status |
Public on May 06, 2020 |
| Title |
Lyve1+ cells expressing BRAFV600E show hepatic vascular cavernomas in developing murine liver. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of whole liver samples from BRAFV600E F/+;Lyve1-Cre/+ murine embryos at embryonic day 11.5. Results provide insights into the role of BRAF gain-of-function mutation in hepatic endothelial cells during development.
We used microarray to investigate the gene expression program affected by endothelial BRAFV600E during liver development and identified patterns of differentially-expressed genes and pathways during this process.
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| Overall design |
Murine embryonic livers were dissected from E11.5 embryos and pooled for RNA extraction and hybridization on Affymetrix microarray chips. We utilized three samples for each genotypes.
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| Contributor(s) |
Janardhan HP, Trivedi CM |
| Citation(s) |
32405640 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 HL141377 |
Epigenetic regulation of lymphatic development |
UNIV OF MASSACHUSETTS MED SCHOOL |
Chinmay M Trivedi |
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| |
| Submission date |
Mar 31, 2020 |
| Last update date |
May 15, 2020 |
| Contact name |
Chinmay Trivedi |
| E-mail(s) |
Chinmay.Trivedi@umassmed.edu
|
| Organization name |
University of Massachusetts Medical School
|
| Department |
Medicine
|
| Street address |
368 Plantation St, AS7-1047
|
| City |
Worcester |
| State/province |
MA |
| ZIP/Postal code |
01605 |
| Country |
USA |
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| Platforms (1) |
| GPL20258 |
[MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CDF version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA622278 |
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