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| Status |
Public on Apr 16, 2009 |
| Title |
Affymetrix SNP array data for low-grade astrocytoma samples |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
|
| Summary |
Copy number analysis of 21 paediatric low-grade astrocytomas identified a discrete copy number gain of 1.9Mb in chromosome band 7q34. The gain was present in 12/14 cerebellar pilocytic astrocytomas. Subsequent analysis of tumour cDNA indentified a novel gene fusion between KIAA1549 and BRAF in these tumours.
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| Overall design |
Copy number analysis of 21 paediatric low-grade astrocytomas using the Affymetrix GeneChip Human Mapping 250K Nsp Array. This study comprised 14 pilocytic astrocytomas, 4 diffuse astrocytomas, one pilomyxoid astrocytoma, one pilomyxoid glioma and one pleomorphic xanthoastrocytoma. Tumours were compared to the mean of two normal male DNA controls.
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| Contributor(s) |
Forshew T, Tatevossian RG, Lawson AR, Chaplin T, Young BD, Ellison DW, Sheer D |
| Citation(s) |
19373855 |
| |
| Submission date |
Feb 23, 2009 |
| Last update date |
May 17, 2017 |
| Contact name |
Tim Forshew |
| E-mail(s) |
t.forshew@qmul.ac.uk
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| Phone |
02078822597
|
| Organization name |
Queen Mary's School of Medicine and Dentistry
|
| Department |
Centre for Neuroscience
|
| Street address |
4 Newark Street
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| City |
London |
| ZIP/Postal code |
E1 2AT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL3718 |
[Mapping250K_Nsp] Affymetrix Mapping 250K Nsp SNP Array |
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| Samples (23)
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| Relations |
| BioProject |
PRJNA111833 |
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