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| Status |
Public on Nov 16, 2020 |
| Title |
RNA sequencing study using Prox1-eGFP mice to investigate the role of lymphatic vasculature in chronic cardiac dysfunction |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The goal of the study is to examine the transcriptional changes in different cell populations isolated from heart and diaphragm in angiotensin II infusion-induced cardiac dysfunction and with a lymphangiogenic therapy (VEGFCc156s)
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| Overall design |
Prox1-eGFP mice were treated with BSA, angiotensin II in BSA or angiotensin II and VEGFCc156s for 5-6 weeks and used for the isolation of different cell populations from heart and diaphragm. The transcriptional profile of isolated cell populations was examined using RNA-Seq.
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| |
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| Contributor(s) |
Song L, Shipstone A, Nagle MW |
| Citation(s) |
33200983 |
| |
| Submission date |
May 07, 2020 |
| Last update date |
Dec 08, 2020 |
| Contact name |
Michael Nagle |
| E-mail(s) |
michael.nagle@pfizer.com
|
| Organization name |
Pfizer
|
| Department |
Internal Medicine Research Unit
|
| Street address |
1 Portland Street
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02140 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA630980 |
| SRA |
SRP260447 |
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