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Series GSE150236 Query DataSets for GSE150236
Status Public on Jun 18, 2020
Title Developmental Programming: Sheep Granulosa and Theca Cell-Specific Transcriptional Regulation by Prenatal Testosterone
Organism Ovis aries
Experiment type Expression profiling by high throughput sequencing
Summary Prenatal testosterone treated sheep, similar to PCOS women, manifest reduced cyclicity, functional hyperandrogenism and polycystic ovary (PCO) morphology. The PCO morphology results from increased follicular recruitment and persistence of antral follicles, consequence of reduced follicular growth and atresia, and driven by cell-specific gene expression changes that are poorly understood. Therefore, utilizing RNA sequencing, cell-specific transcriptional changes were assessed in laser capture microdissection isolated antral follicular granulosa and theca cells from 21 months-of- age control and prenatal testosterone treated sheep.
 
Overall design 5 control sheep and 5 prenatal testosterone treated sheep, each with a theca cell and granulosa cell sample
 
Contributor(s) Puttabyatappa M, Dou J, Guo X, Dumesic D, Bakulski KM, Padmanabhan V
Citation(s)
  • Puttabyatappa M, Guo X, Dou J, Dumesic D et al. Developmental Programming: Sheep Granulosa and Theca Cell-Specific Transcriptional Regulation by Prenatal Testosterone. Endocrinology 2020 Aug 1;161(8). PMID: 32516392
Submission date May 11, 2020
Last update date Jul 30, 2020
Contact name Kelly Bakulski
E-mail(s) bakulski@umich.edu
Organization name University of Michigan
Department Department of Epidemiology
Street address 1415 Washington Heights
City Ann Arbor
State/province MI
ZIP/Postal code 48109
Country USA
 
Platforms (1)
GPL27721 Illumina NovaSeq 6000 (Ovis aries)
Samples (20)
GSM4543852 GC139C
GSM4543853 GC244C
GSM4543854 GC246C
Relations
BioProject PRJNA631614
SRA SRP261061

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE150236_normalized_counts.csv.gz 2.6 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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