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Status |
Public on May 19, 2020 |
Title |
Investigation of the molecular effects of a dexpanthenol-containing ointment and liquid in the aftercare treatment of acute radiodermatitis and mucositis using newly developed 3D models for both skin conditions |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
This study aimed to investigate the molecular effects of radiation and subsequent aftercare treatment with dexpanthenol-containing ointment and liquid on newly established full-thickness 3D skin models depicting acute radiodermatitis and mucositis. We established in vitro models of the non-keratinized mucous membrane as well as normal human skin models. To mimic radiomucositis and radiodermatitis, models were irradiated with 5 Gray. Afterwards, models were treated topically every second day with dexpanthenol-containing ointment or liquid in comparison to placebo and untreated controls.
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Overall design |
Six samples were analyzed: 5Gy-treated radiodermatitis model vs. control radiodermatitis; 5Gy-treated mucositis vs. control mucositis; 5Gy-treated + dexpanthenol-containing ointment radiodermatitis vs. 5Gy-treated radiodermatitis; 5Gy-treated + dexpanthenol-containing liquid mucositis vs. 5Gy-treated mucositis.
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Contributor(s) |
Huth S, Marquardt Y, Huth L, Schmitt L, Prescher K, Winterhalder P, Steiner T, Hölzle F, Eble M, Baron JM |
Citation missing |
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Submission date |
May 18, 2020 |
Last update date |
May 21, 2020 |
Contact name |
Sebastian Huth |
Organization name |
Uniklinik RWTH Aachen
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Street address |
Pauwelsstr. 30
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City |
Aachen |
ZIP/Postal code |
52074 |
Country |
Germany |
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Platforms (1) |
GPL23159 |
[Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay) |
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Samples (6)
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Relations |
BioProject |
PRJNA633484 |