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Series GSE150738 Query DataSets for GSE150738
Status Public on May 19, 2020
Title Investigation of the molecular effects of a dexpanthenol-containing ointment and liquid in the aftercare treatment of acute radiodermatitis and mucositis using newly developed 3D models for both skin conditions
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This study aimed to investigate the molecular effects of radiation and subsequent aftercare treatment with dexpanthenol-containing ointment and liquid on newly established full-thickness 3D skin models depicting acute radiodermatitis and mucositis. We established in vitro models of the non-keratinized mucous membrane as well as normal human skin models. To mimic radiomucositis and radiodermatitis, models were irradiated with 5 Gray. Afterwards, models were treated topically every second day with dexpanthenol-containing ointment or liquid in comparison to placebo and untreated controls.
 
Overall design Six samples were analyzed: 5Gy-treated radiodermatitis model vs. control radiodermatitis; 5Gy-treated mucositis vs. control mucositis; 5Gy-treated + dexpanthenol-containing ointment radiodermatitis vs. 5Gy-treated radiodermatitis; 5Gy-treated + dexpanthenol-containing liquid mucositis vs. 5Gy-treated mucositis.
 
Contributor(s) Huth S, Marquardt Y, Huth L, Schmitt L, Prescher K, Winterhalder P, Steiner T, Hölzle F, Eble M, Baron JM
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Submission date May 18, 2020
Last update date May 21, 2020
Contact name Sebastian Huth
Organization name Uniklinik RWTH Aachen
Street address Pauwelsstr. 30
City Aachen
ZIP/Postal code 52074
Country Germany
 
Platforms (1)
GPL23159 [Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay)
Samples (6)
GSM4557961 1_3D26_18_Kontrolle-1_d7
GSM4557962 2_3D26_18_5GY-1_d7
GSM4557963 3_3D26_18_5GY+DCO 1_d7
Relations
BioProject PRJNA633484

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE150738_RAW.tar 6.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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