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Series GSE150801 Query DataSets for GSE150801
Status Public on May 19, 2020
Title Varenicline reduces ethanol consumption in male C57BL/6J mice: Potential gene expression mechanisms
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In recent years, varenicline has been shown to decrease ethanol consumption in adult rodents providing support as a therapeutic treatment for alcohol use disorder (AUD). Varenicline is a partial agonist at alpha4beta2 nicotinic acetylcholine receptors, but interacts with other receptors at high concentrations. In order to gain a greater understanding of the mechanisms by which varenicline decreases ethanol consumption, we performed RNA sequencing on striatal tissue from C57BL/6J mice treated with varenicline or saline prior to an ethanol Drinking-in-the-Dark (DID) session. Using classical tools to analyze RNA sequencing data, we found 809 differentially expressed genes with Cuffdiff and one significant co-expression network using WGCNA.
 
Overall design Striatal gene expression from animals treated with saline or 2 mg/kg varenicline prior to ethanol Drinking-in-the-Dark
 
Contributor(s) Kamens HM, Dziak JJ, Horton WJ, Silva CP, Sebastian A, Albert I, Li R
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date May 18, 2020
Last update date May 19, 2020
Contact name Aswathy Sebastian
E-mail(s) azs13@psu.edu
Phone 5204613475
Organization name PennState
Street address University Park
City State College
ZIP/Postal code 16801
Country USA
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (12)
GSM4558961 A SAL (rep1)
GSM4558962 B SAL (rep1)
GSM4558963 F VAR (rep 1)
Relations
BioProject PRJNA633622
SRA SRP262213

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE150801_genes_cuffnorm_vals.txt.gz 889.1 Kb (ftp)(http) TXT
GSE150801_genes_raw_counts.txt.gz 2.3 Mb (ftp)(http) TXT
GSE150801_samples_FPKM.txt.gz 1.2 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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