|
| Status |
Public on Dec 07, 2020 |
| Title |
On the NF-Y regulome as in ENCODE (2019) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The ongoing ENCODE consortium represents a useful compendium of locations of TFs, chromatin marks, gene expression data. In previous reports, we identified modules of CCAAT-binding NF-Y with individual TFs. Here, we analyzed all 363 factors currently present: 68 with enrichment of CCAAT in their locations, 38 with overlap of peaks. New sequence-specific TFs, co-activators and co-repressors are reported. Co-association patterns correspond to specific targeted genes categorizations and gene expression changes, as assessed by RNA-seq after NF-Y inactivation. These data widen and better define a coherent model of synergy of NF-Y with selected groups of TFs and cofactors.
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| |
|
| Overall design |
RNA-seq of HeLa cell line after inactivation of NF-YB.
|
| |
|
| Contributor(s) |
Dolfini D, Bernardini A, Ronzio M |
| Citation(s) |
33370256 |
| |
| Submission date |
May 26, 2020 |
| Last update date |
Feb 01, 2021 |
| Contact name |
Diletta Dolfini |
| E-mail(s) |
diletta.dolfini@unimi.it
|
| Organization name |
University of Milan
|
| Department |
Bioscience
|
| Street address |
Via Celoria, 26
|
| City |
Milano |
| State/province |
MI |
| ZIP/Postal code |
20133 |
| Country |
Italy |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA635200 |
| SRA |
SRP264849 |
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