|
| Status |
Public on Mar 05, 2010 |
| Title |
EGR1 regulates metastatic potential of v-src transformed chicken sarcoma cell lines |
| Organism |
Gallus gallus |
| Experiment type |
Expression profiling by array
|
| Summary |
A model of tumor metastasis based on v-src transformed immortalized cell lines was developed. The model consists of highly metastatic PR9692 cell line and a derived clone PR9692-E9 which has lost the metastatic abilities. Introduction of exogenous EGR1 gene into the non-metastasizing PR9692-E9 cells completely restores the metastatic potential. Revealed changes in gene expression provide insight into the molecular mechanisms contolling metastatic behavior of sarcoma cells.
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| |
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| Overall design |
Comparison of expression profiles obtained from highly metastatic PR9692 cell line, derived non-metastatic clone PR9692-E9 and non-metastatic PR9692-E9 cells infected with replication-defective retroviral vector SFCVneo-EGR1 containing full length cDNA of EGR1. For each condition three biological replicates were analyzed.
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| |
|
| Contributor(s) |
Cermak V |
| Citation(s) |
20505979 |
| |
| Submission date |
Mar 06, 2009 |
| Last update date |
Mar 21, 2012 |
| Contact name |
Robert Ivanek |
| Phone |
+41 61 207 35 41
|
| Organization name |
University of Basel
|
| Department |
Department of Biomedicine
|
| Lab |
Bioinformatics
|
| Street address |
Hebelstrasse 20
|
| City |
Basel |
| ZIP/Postal code |
4053 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL3213 |
[Chicken] Affymetrix Chicken Genome Array |
|
| Samples (9)
|
| GSM378241 |
PR9692 metastasizing cell line, replicate 1 |
| GSM378242 |
PR9692 metastasizing cell line, replicate 2 |
| GSM378243 |
PR9692 metastasizing cell line, replicate 3 |
| GSM378244 |
PR9692-E9 non-metastasizing cell line, replicate 1 |
| GSM378245 |
PR9692-E9 non-metastasizing cell line, replicate 2 |
| GSM378246 |
PR9692-E9 non-metastasizing cell line, replicate 3 |
| GSM378247 |
PR9692-E9-EGR1 metastasizing cell line, replicate 1 |
| GSM378248 |
PR9692-E9-EGR1 metastasizing cell line, replicate 2 |
| GSM378249 |
PR9692-E9-EGR1 metastasizing cell line, replicate 3 |
|
| Relations |
| BioProject |
PRJNA114903 |
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