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Series GSE151661 Query DataSets for GSE151661
Status Public on Jun 03, 2020
Title Transcriptomic expression profiles of SPF chicken-lung infected with duck-origin H7N9 subtype avian influenza virus
Organism Gallus gallus
Experiment type Expression profiling by high throughput sequencing
Summary In order to elucidate the expression changes of host genes of SPF chickens infected with duck-origin H7N9 subtype avian influenza virus. The lungs of SPF chickens infected with duck-origin H7N9 subtype avian influenza virus were collected and high throughout sequenced. Compared with the control group, there were 740 differentially expressed genes were obtained in infection group, including 602 up-regulated genes and 138 down-regulated genes. The analysis of the GO items showed that the differentially expressed genes were involved in immune responses and inflammatory responses. The results of KEGG analysis showed that 7 pathways were enriched significantly, in those the Toll-like pathway had 11 up-regulated genes, namely IL-6, TLR4, Pik3, IRF7, MD-2, IRF5, MYD88, CD86, STAT1, TLR2, and CCL4. There were 7 up-regulated genes in NOD-like receptor signaling pathway, which were IRF7, CTSB, P2RX7, CYBB, PSTPIP1, HSP90AA1, and NAMPT. In Toll-like signaling pathway,TLR4 was activated by MD-2 after viral infection, and then activated downstream IRF5. At the same time, the NLRP3 inflammasome also played an important role in the process of H7N9 virus infection.
 
Overall design Lung mRNA profiles of SPF chickens infected with duck-origin H7N9 AIV and control were generated by deep sequencing, in triplicate, using Illumina X ten.
 
Contributor(s) Shi S
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Submission date Jun 02, 2020
Last update date Jun 03, 2020
Contact name Shaohua Shi
E-mail(s) shaohua115@163.com
Organization name Yangzhou University
Department College of Veterinary Medicine
Street address 48 East Wenhui Road
City Yangzhou
State/province Jiangsu
ZIP/Postal code 225009
Country China
 
Platforms (1)
GPL24517 HiSeq X Ten (Gallus gallus)
Samples (6)
GSM4587811 duizhao-fei-1
GSM4587812 duizhaofei-2
GSM4587813 duizhao-fei-3
Relations
BioProject PRJNA636788
SRA SRP265640

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE151661_1015gene_expression.txt.gz 1.7 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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