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| Status |
Public on Jun 08, 2020 |
| Title |
RNA-seq analysis of mouse retinas from animals treated with 140mg/kg/day Vigabatrin |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The goal of this study was to look at the effects of the anti epeleptic drug Vigabatrin on retinal transcripts.
Vigabatrin altered transcripts related to phototransduction, neuronal function and synaptic plasticity.
This is the first study showing that vigabatrin has an effect on the retinal transcriptome
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| Overall design |
Methods: C57/Bl6 (Week 10-12) Mice were treated with Vigabatrin via subcutaneous osmotic pump for 11 days. At DOL 11, mice were sacrificed and retinas were extracted, flash frozen and stored at -80 prior to RNA extraction.
[contributor] Novogene Inc.
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| |
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| Contributor(s) |
Walters D, Gibson M, Roullet J |
| Citation(s) |
32679486 |
| |
| Submission date |
Jun 07, 2020 |
| Last update date |
Sep 07, 2020 |
| Contact name |
Mike Gibson |
| E-mail(s) |
mike.gibson@wsu.edu
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| Phone |
5093686602
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| Organization name |
Washington State University
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| Department |
Pharmacotherapy
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| Street address |
412 E Spokane Falls Blvd
|
| City |
Spokane |
| State/province |
Washington |
| ZIP/Postal code |
99202 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA637887 |
| SRA |
SRP266313 |
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