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Series GSE152702 Query DataSets for GSE152702
Status Public on Sep 08, 2020
Title Circulating miR-16-5p, miR-92a-3p, and miR-451a in plasma from lung cancer patients: potential application in early detection and a regulatory role in tumorigenesis pathways.
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Micro(mi)RNAs, potent gene expression regulators associated with tumorigenesis, are stable, abundant circulating molecules,that are detectable in plasma. Thus, miRNAs could potentially be useful in early lung cancer detection.We aimed to identify circulating miRNA signatures in plasma from patients with lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), and to verify whether miRNAs regulate pathways of lung oncogenesis.
 
Overall design RNA isolated from 139 plasma samples (40 LUAD;38 LUSC;61 healthy/non-diseased individuals) were divided into discovery (38 patients; 7 controls including 21 samples, for expression quantification usingan 800-miRNA panel; NanostringnCounter®)and validation (40 patients; 40 controls; TaqMan®RT-qPCR)cohorts. Elastic net, Maximizing-R-Square Analysis (MARSA), and C-Statistics were applied for miRNA signature identification.
 
Contributor(s) Reis PP, Drigo SA, Carvalho RF, Lopez Lapa RM, Felix TF, Patel D, Cheng D, Pintilie M, Liu G, Tsao MS
Citation(s) 32726984
Submission date Jun 17, 2020
Last update date Sep 08, 2020
Contact name Tainara Francini Felix
E-mail(s) felix.tainara@gmail.com
Phone 14996257103
Organization name UNESP
Department Surgery and Orthopedics
Street address Av. Prof. Mário Rubens Guimarães Montenegro, s/n, s/n
City Botucatu
State/province SP
ZIP/Postal code 18618-687
Country Brazil
 
Platforms (1)
GPL24158 NanoString nCounter Human v3 miRNA Assay (NS_H_miR_v3a)
Samples (45)
GSM4624064 Patient 1058
GSM4624065 Patient 1079
GSM4624066 Patient 1129
Relations
BioProject PRJNA640153

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE152702_RAW.tar 360.0 Kb (http)(custom) TAR (of RCC)
Processed data included within Sample table

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