|
Status |
Public on Nov 20, 2020 |
Title |
A microRNA cluster in the DLK1-DIO3 imprinted region on chromosome 14q32.2 in hepatoblastoma |
Platform organism |
synthetic construct |
Sample organism |
Homo sapiens |
Experiment type |
Non-coding RNA profiling by array
|
Summary |
Using array-based expression analysis on formalin-fixed paraffin-embedded tissues, we aimed to identify miRNA signatures that can discriminate between lung metastatic tumors, primary tumors (fetal and embryonal subtypes) and nontumorous surrounding livers. A large cluster of microRNAs and snoRNAs located within the 14q32.2 DLK1-DIO3 region showed a strikingly upregulated expression pattern in HB tumors, especially metastatic tumors, compared to normal liver tissues.
|
|
|
Overall design |
Here we examined microRNAs and snoRNAs profiles related to different type of hepatoblastoma tumor cells, using array-based expression analysis.
|
|
|
Contributor(s) |
Honda S, Chatterjee A, Leichter AL, Eccles MR |
Citation(s) |
33282720 |
|
Submission date |
Jun 23, 2020 |
Last update date |
Dec 08, 2020 |
Contact name |
Shohei Honda |
E-mail(s) |
s-honda@med.hokudai.ac.jp
|
Phone |
0117065927
|
Organization name |
Hokkaido University Hospital
|
Department |
Department of Gastroenterological surgery I
|
Street address |
Kita-14,Nishi-5
|
City |
Sapporo |
ZIP/Postal code |
060-8648 |
Country |
Japan |
|
|
Platforms (1) |
GPL21572 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array [ProbeSet ID version] |
|
Samples (44)
|
|
Relations |
BioProject |
PRJNA641410 |