|
| Status |
Public on Apr 01, 2022 |
| Title |
HOXB13 inhibits lipid metabolism through HDAC3-mediated epigenetic reprogramming [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
HOXB13 is a homeodomain transcription factor with prostate-specific expression. It is essential for normal prostate epithelium differentiation during development and functions as a key regulator of androgen-dependent cell growth in adult and cancerous prostate. Previous studies have demonstrated that HOXB13 is a pioneer factor of the androgen receptor (AR) and also a critical cofactor of AR variant v7 in castration-resistant prostate cancer (PCa). However, the intrinsic function of HOXB13 as a DNA-binding protein in an AR-independent context has not been elucidated. Here, our data reveal HOXB13, but not G84E mutant, recruits HDAC3 to specific genomic regions to catalyze histone de-acetylation and chromatin remodeling. We demonstrate a predominant function of HOXB13 in transcriptional repression of lipogenic genes requiring HDAC3.
|
| |
|
| Overall design |
RNA-seq of prostate cancer cells with HOXB13 and/or HDAC3 de-regulation
|
| |
|
| Contributor(s) |
Yu J, Lu X |
| Citation(s) |
35468964 |
| |
| Submission date |
Jun 30, 2020 |
| Last update date |
May 16, 2022 |
| Contact name |
Jindan Yu |
| E-mail(s) |
jindan.yu@emory.edu
|
| Organization name |
Emory University
|
| Department |
Urology
|
| Lab |
Jindan Yu's lab
|
| Street address |
E330, 1760 Haygood Dr NE
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30322 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (24)
|
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| This SubSeries is part of SuperSeries: |
| GSE153586 |
HOXB13 inhibits lipid metabolism through HDAC3-mediated epigenetic reprogramming |
|
| Relations |
| BioProject |
PRJNA643277 |
| SRA |
SRP269431 |
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