|
| Status |
Public on Feb 12, 2021 |
| Title |
Analysis of senescence transcriptome upon knockdown of XPO7 [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We depleted XPO7 by shRNA in IMR90 ER:RAS cells. 5 days after RAS induction by treatment with 4OHT we collected RNA. XPO7 depletion alleviates senescence induction.
|
| |
|
| Overall design |
4 conditions in triplicate. IMR90 ER:RAS cells, either: non-induced control cells (non-senescent), 4OHT induced cells (Senescent, induced), IMR90 ER:RAS cells, 4OHT-induced and with XPO7 depletion (by expressing shXPO7_3), IMR90 ER:RAS cells, 4OHT-induced and with XPO7 depletion (by expressing shXPO7_5)
|
| |
|
| Contributor(s) |
Innes A, Gil J, Dharmalingam G, Pallikonda HA |
| Citation(s) |
33602872 |
| |
| Submission date |
Jul 07, 2020 |
| Last update date |
Mar 23, 2021 |
| Contact name |
LMS Bioinformatics Core |
| E-mail(s) |
bioinformatics@lms.mrc.ac.uk
|
| Organization name |
MRC London Institute of Medical Sciences
|
| Department |
Bioinformatics Core
|
| Street address |
Hammersmith Hospital Campus, Du Cane Road
|
| City |
London |
| ZIP/Postal code |
W12 0NN |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA644552 |
| SRA |
SRP270635 |
Less...
More...