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| Status |
Public on Jul 08, 2020 |
| Title |
Gene expression profiles of wild type, Nr4a-triple knockout (Nr4a-TKO), and Foxp3-KO iTreg 24 h |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we investigated the roles of Nr4a family transcription factors in Th and Treg cell differentiation from Tnaive cells. Nr4a factors were found to promote Treg cell differentiation and repress Th1 and Th2 differentiation. During Treg cell differentiation, all Nr4a factors are transiently induced in Tnaive cells immediately after TCR stimulation, whereby they mediate epigenetic changes directly or by cooperating with other transcription factors. To reveal Nr4a factors' mediated transcrptional events, we analyzed gene expression of wild type and Nr4a1,a2,a3-tripple knockout (Nr4a-TKO) iTreg cells by microarray analysis.
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| Overall design |
Wild type, Nr4a-TKO, and Foxp3 KO iTreg cells after 24 h differentiation were analyzed.
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| Contributor(s) |
Sekiya T, Kagawa S, Masaki K, Fukunaga K, Yoshimura A, Takaki S |
| Citation(s) |
33665581 |
| |
| Submission date |
Jul 07, 2020 |
| Last update date |
Mar 11, 2021 |
| Contact name |
Takashi Sekiya |
| E-mail(s) |
lb-sekiya@hospk.ncgm.go.jp
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| Organization name |
National Center for Global Health and Medicine
|
| Street address |
1-7-1 Kohnodai
|
| City |
Ichikawa |
| State/province |
Chiba |
| ZIP/Postal code |
272-0827 |
| Country |
Japan |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (3) |
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| This SubSeries is part of SuperSeries: |
| GSE153928 |
Roles of Nr4a family transcription factors in Th and Treg cell differentiation from Tnaive cells |
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| Relations |
| BioProject |
PRJNA644559 |
