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| Status |
Public on Nov 27, 2020 |
| Title |
Deletion of the gene encoding the N-methyl-D Aspartate Receptor GluN1 subunit in Schwann cells causes ultrastructural changes in Remak bundles and hypersensitivity in pain processing |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Mouse DRGs (n=3 per genotype) were isolated from a novel mouse model with conditional deletion of Glun1 in Schwann cells (GluN1-) and corresponding littermate controls (Glun+). P0Cre recombinase is the driver. Transcriptome profiling of DRGs revealed 138 differenially regulated genes in Glun1- mice. On third of the regulated genes are known to be involved in pain processing.
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| |
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| Overall design |
6 samples total. Examined differential expression between wildtype DRG (n=3) versus NMDA-R knockout DRG (n=3).
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| |
|
| Contributor(s) |
Campana W |
| Citation(s) |
33051351 |
| |
| Submission date |
Jul 10, 2020 |
| Last update date |
Nov 27, 2020 |
| Contact name |
Wendy Marie Campana |
| E-mail(s) |
wcampana@health.ucsd.edu
|
| Organization name |
University of California San Diego
|
| Department |
Anesthesiology
|
| Lab |
Campana
|
| Street address |
9500 Gilman Drive
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093-0629 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA645377 |
| SRA |
SRP271253 |
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