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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 17, 2021 |
| Title |
Comparative analysis of glioblastoma initiating cells and patient-matched EPSC-derived neural stem cells as a discovery tool and drug matching strategy [Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
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| Summary |
Malignant gliomas are the most common intrinsic brain tumours in adults and are associated with a very poor prognosis, which has not improved in the last 20 years. We show here that glioblastoma initiating cells (GIC) and syngeneic neural stem cells derived from enhanced pluripotent stem cells (iNSC) are a suitable novel pre-clinical pipeline to discover new patient-specific disease mechanisms and to identify druggable targets for personalised therapy.
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| Overall design |
Transcriptomic and DNA methylation analysis of murine eNSC and two classes of induced NSC
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| Contributor(s) |
Vinel C, Pomella N, Marino S |
| Citation(s) |
34675201 |
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| Submission date |
Jul 13, 2020 |
| Last update date |
Oct 27, 2021 |
| Contact name |
Silvia Marino |
| E-mail(s) |
s.marino@qmul.ac.uk
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| Organization name |
Queen Mary University of London
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| Street address |
4, Newark St
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| City |
London |
| State/province |
- |
| ZIP/Postal code |
E12AT |
| Country |
United Kingdom |
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| Platforms (2) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (30)
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| GSM4669670 |
eNSC 1, rep 2 |
| GSM4669671 |
eNSC 2. rep 2 |
| GSM4669672 |
eNSC 3, rep 2 |
| GSM4669673 |
iNSC 1, rep 1, N2B27 protocol |
| GSM4669674 |
iNSC 2, rep 1, N2B27 protocol |
| GSM4669675 |
iNSC 3, rep 1, N2B27 protocol |
| GSM4669676 |
iNSC 1, rep 1, Gibco protocol |
| GSM4669677 |
iNSC 2, rep 1, Gibco protocol |
| GSM4669678 |
iNSC 3, rep 1, Gibco protocol |
| GSM4669679 |
iNSC 1, rep 2, N2B27 protocol |
| GSM4669680 |
iNSC 1, rep 3, N2B27 protocol |
| GSM4669681 |
iNSC 1, rep 2, Gibco protocol |
| GSM4669682 |
iNSC 1, rep 3, Gibco protocol |
| GSM4669683 |
iNSC 3, rep 2, N2B27 protocol |
| GSM4669684 |
iNSC 3, rep 3, N2B27 protocol |
| GSM4669685 |
iNSC 3, rep 2, Gibco protocol |
| GSM4669686 |
iNSC 3, rep 3, Gibco protocol |
| GSM4669687 |
iNSC 2, rep 2, N2B27 protocol |
| GSM4669688 |
iNSC 2, rep 3, N2B27 protocol |
| GSM4669689 |
iNSC 2, rep 2, Gibco protocol |
| GSM4669690 |
iNSC 2, rep 3, Gibco protocol |
| GSM4669691 |
RRBS_eNSC 1, rep 1 |
| GSM4669692 |
RRBS_eNSC 2, rep 1 |
| GSM4669693 |
RRBS_eNSC 3, rep 1 |
| GSM4669694 |
RRBS_iNSC 1, rep 1, Gibco protocol |
| GSM4669695 |
RRBS_iNSC 2, rep 1, Gibco protocol |
| GSM4669696 |
RRBS_iNSC 3, rep 1, Gibco protocol |
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| This SubSeries is part of SuperSeries: |
| GSE155994 |
Comparative analysis of glioblastoma initiating cells and patient-matched EPSC-derived neural stem cells as a discovery tool and drug matching strategy |
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| Relations |
| BioProject |
PRJNA645954 |
| SRA |
SRP271665 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE154367_RAW.tar |
466.4 Mb |
(http)(custom) |
TAR (of COV) |
| GSE154367_mouseTPM.csv.gz |
2.2 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
| Processed data provided as supplementary file |
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